Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect

SAMHD1, a dNTP triphosphohydrolase, contributes to interferon signaling and restriction of retroviral replication. SAMHD1-mediated retroviral restriction is thought to result from the depletion of cellular dNTP pools, but it remains controversial whether the dNTPase activity of SAMHD1 is sufficient...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhattacharya, Akash, Wang, Zhonghua, White, Tommy, Buffone, Cindy, Nguyen, Laura A., Shepard, Caitlin N., Kim, Baek, Demeler, Borries, Diaz-Griffero, Felipe, Ivanov, Dmitri N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980677/
https://www.ncbi.nlm.nih.gov/pubmed/27511536
http://dx.doi.org/10.1038/srep31353

Ejemplares similares

Ejemplares similares