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TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye

An intractable challenge in glaucoma treatment has been to identify druggable targets within the conventional aqueous humor outflow pathway, which is thought to be regulated/dysregulated by elusive mechanosensitive protein(s). Here, biochemical and functional analyses localized the putative mechanos...

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Detalles Bibliográficos
Autores principales:	Ryskamp, Daniel A., Frye, Amber M., Phuong, Tam T. T., Yarishkin, Oleg, Jo, Andrew O., Xu, Yong, Lakk, Monika, Iuso, Anthony, Redmon, Sarah N., Ambati, Balamurali, Hageman, Gregory, Prestwich, Glenn D., Torrejon, Karen Y., Križaj, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980693/ https://www.ncbi.nlm.nih.gov/pubmed/27510430 http://dx.doi.org/10.1038/srep30583

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