Systematically Altering Bacterial SOS Activity under Stress Reveals Therapeutic Strategies for Potentiating Antibiotics

The bacterial SOS response is a DNA damage repair network that is strongly implicated in both survival and acquired drug resistance under antimicrobial stress. The two SOS regulators, LexA and RecA, have therefore emerged as potential targets for adjuvant therapies aimed at combating resistance, alt...

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Detalles Bibliográficos
Autores principales: Mo, Charlie Y., Manning, Sara A., Roggiani, Manuela, Culyba, Matthew J., Samuels, Amanda N., Sniegowski, Paul D., Goulian, Mark, Kohli, Rahul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980697/
https://www.ncbi.nlm.nih.gov/pubmed/27536734
http://dx.doi.org/10.1128/mSphere.00163-16

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