Cargando…

Hypertension and risk of prostate cancer: a systematic review and meta-analysis

The previously reported association between hypertension and prostate cancer risk was controversial. We performed this systematic review and meta-analysis of all available studies to summarize evidence on this association. Studies were identified by searching PubMed, Web of Science and Chinese Natio...

Descripción completa

Detalles Bibliográficos
Autores principales: Liang, Zhen, Xie, Bo, Li, Jiangfeng, Wang, Xiao, Wang, Song, Meng, Shuai, Ji, Alin, Zhu, Yi, Xu, Xin, Zheng, Xiangyi, Xie, Liping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980763/
https://www.ncbi.nlm.nih.gov/pubmed/27511796
http://dx.doi.org/10.1038/srep31358
_version_ 1782447510428581888
author Liang, Zhen
Xie, Bo
Li, Jiangfeng
Wang, Xiao
Wang, Song
Meng, Shuai
Ji, Alin
Zhu, Yi
Xu, Xin
Zheng, Xiangyi
Xie, Liping
author_facet Liang, Zhen
Xie, Bo
Li, Jiangfeng
Wang, Xiao
Wang, Song
Meng, Shuai
Ji, Alin
Zhu, Yi
Xu, Xin
Zheng, Xiangyi
Xie, Liping
author_sort Liang, Zhen
collection PubMed
description The previously reported association between hypertension and prostate cancer risk was controversial. We performed this systematic review and meta-analysis of all available studies to summarize evidence on this association. Studies were identified by searching PubMed, Web of Science and Chinese National Knowledge Infrastructure (CNKI) databases through January 2016. Pooled relative risks (RRs) with their corresponding 95% confidence intervals (CIs) were calculated using a random-effects model. A total of 21 published studies were included in this meta-analysis. A significant increase in the risk of prostate cancer (RR 1.08, 95% CI 1.02–1.15, P = 0.014) was observed among individuals with hypertension. There was statistically significant heterogeneity among included studies (P < 0.001 for heterogeneity, I(2) = 72.1%). No obvious evidence of significant publication bias was detected by either Begg’s test (P = 0.174) or Egger’s test (P = 0.277). In conclusion, this meta-analysis indicates that hypertension may be associated with an increased risk of prostate cancer. Considering the substantial heterogeneity and residual confounding among included studies, further large-scale, well-designed prospective cohorts, as well as mechanistic studies, are urgently needed to confirm our preliminary findings.
format Online
Article
Text
id pubmed-4980763
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-49807632016-08-19 Hypertension and risk of prostate cancer: a systematic review and meta-analysis Liang, Zhen Xie, Bo Li, Jiangfeng Wang, Xiao Wang, Song Meng, Shuai Ji, Alin Zhu, Yi Xu, Xin Zheng, Xiangyi Xie, Liping Sci Rep Article The previously reported association between hypertension and prostate cancer risk was controversial. We performed this systematic review and meta-analysis of all available studies to summarize evidence on this association. Studies were identified by searching PubMed, Web of Science and Chinese National Knowledge Infrastructure (CNKI) databases through January 2016. Pooled relative risks (RRs) with their corresponding 95% confidence intervals (CIs) were calculated using a random-effects model. A total of 21 published studies were included in this meta-analysis. A significant increase in the risk of prostate cancer (RR 1.08, 95% CI 1.02–1.15, P = 0.014) was observed among individuals with hypertension. There was statistically significant heterogeneity among included studies (P < 0.001 for heterogeneity, I(2) = 72.1%). No obvious evidence of significant publication bias was detected by either Begg’s test (P = 0.174) or Egger’s test (P = 0.277). In conclusion, this meta-analysis indicates that hypertension may be associated with an increased risk of prostate cancer. Considering the substantial heterogeneity and residual confounding among included studies, further large-scale, well-designed prospective cohorts, as well as mechanistic studies, are urgently needed to confirm our preliminary findings. Nature Publishing Group 2016-08-11 /pmc/articles/PMC4980763/ /pubmed/27511796 http://dx.doi.org/10.1038/srep31358 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Liang, Zhen
Xie, Bo
Li, Jiangfeng
Wang, Xiao
Wang, Song
Meng, Shuai
Ji, Alin
Zhu, Yi
Xu, Xin
Zheng, Xiangyi
Xie, Liping
Hypertension and risk of prostate cancer: a systematic review and meta-analysis
title Hypertension and risk of prostate cancer: a systematic review and meta-analysis
title_full Hypertension and risk of prostate cancer: a systematic review and meta-analysis
title_fullStr Hypertension and risk of prostate cancer: a systematic review and meta-analysis
title_full_unstemmed Hypertension and risk of prostate cancer: a systematic review and meta-analysis
title_short Hypertension and risk of prostate cancer: a systematic review and meta-analysis
title_sort hypertension and risk of prostate cancer: a systematic review and meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980763/
https://www.ncbi.nlm.nih.gov/pubmed/27511796
http://dx.doi.org/10.1038/srep31358
work_keys_str_mv AT liangzhen hypertensionandriskofprostatecancerasystematicreviewandmetaanalysis
AT xiebo hypertensionandriskofprostatecancerasystematicreviewandmetaanalysis
AT lijiangfeng hypertensionandriskofprostatecancerasystematicreviewandmetaanalysis
AT wangxiao hypertensionandriskofprostatecancerasystematicreviewandmetaanalysis
AT wangsong hypertensionandriskofprostatecancerasystematicreviewandmetaanalysis
AT mengshuai hypertensionandriskofprostatecancerasystematicreviewandmetaanalysis
AT jialin hypertensionandriskofprostatecancerasystematicreviewandmetaanalysis
AT zhuyi hypertensionandriskofprostatecancerasystematicreviewandmetaanalysis
AT xuxin hypertensionandriskofprostatecancerasystematicreviewandmetaanalysis
AT zhengxiangyi hypertensionandriskofprostatecancerasystematicreviewandmetaanalysis
AT xieliping hypertensionandriskofprostatecancerasystematicreviewandmetaanalysis