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Stratification of responders towards eculizumab using a structural epitope mapping strategy
The complement component 5 (C5)-binding antibody eculizumab is used to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical haemolytic uremic syndrome (aHUS). As recently reported there is a need for a precise classification of eculizumab responsive patients to allow for a safe...
Autores principales: | Volk, Anna-Luisa, Hu, Francis Jingxin, Berglund, Magnus M., Nordling, Erik, Strömberg, Patrik, Uhlen, Mathias, Rockberg, Johan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980765/ https://www.ncbi.nlm.nih.gov/pubmed/27509843 http://dx.doi.org/10.1038/srep31365 |
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