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The use of (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) as a pathway-specific biomarker with AZD8186, a PI3Kβ/δ inhibitor

BACKGROUND: The phosphatidylinositol 3 kinase (PI3K) signalling pathway is frequently altered in human cancer and a promising therapeutic target. AZD8186 (AstraZeneca) is a PI3Kβ/δ inhibitor, currently in phase 1 clinical trials. (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET)...

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Detalles Bibliográficos
Autores principales:	Maynard, Juliana, Emmas, Sally-Ann, Blé, Francois-Xavier, Barjat, Hervé, Lawrie, Emily, Hancox, Urs, Oakes, Deborah, Polanska, Urszula M., Barry, Simon T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980858/ https://www.ncbi.nlm.nih.gov/pubmed/27515445 http://dx.doi.org/10.1186/s13550-016-0220-9

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