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Silencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death

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Runt-related transcription factor 2 (RUNX2) has been considered to be one of master regulators for osteoblast differentiation and bone formation. Recently, we have described that RUNX2 attenuates p53/TAp73-dependent cell death of human osteosarcoma U2OS cells bearing wild-type p53 in response to adr...

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Detalles Bibliográficos
Autores principales:	Sugimoto, H, Nakamura, M, Yoda, H, Hiraoka, K, Shinohara, K, Sang, M, Fujiwara, K, Shimozato, O, Nagase, H, Ozaki, T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981025/ https://www.ncbi.nlm.nih.gov/pubmed/27551445 http://dx.doi.org/10.1038/cddiscovery.2015.10

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