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Comparative genomic analysis of Brazilian Leptospira kirschneri serogroup Pomona serovar Mozdok

Leptospira kirschneri is one of the pathogenic species of the Leptospira genus. Human and animal infection from L. kirschneri gained further attention over the last few decades. Here we present the isolation and characterisation of Brazilian L. kirschneri serogroup Pomona serovar Mozdok strain M36/0...

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Autores principales: Moreno, Luisa Z, Kremer, Frederico S, Miraglia, Fabiana, Loureiro, Ana P, Eslabao, Marcus R, Dellagostin, Odir A, Lilenbaum, Walter, Moreno, Andrea M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981118/
https://www.ncbi.nlm.nih.gov/pubmed/27581124
http://dx.doi.org/10.1590/0074-02760160174
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author Moreno, Luisa Z
Kremer, Frederico S
Miraglia, Fabiana
Loureiro, Ana P
Eslabao, Marcus R
Dellagostin, Odir A
Lilenbaum, Walter
Moreno, Andrea M
author_facet Moreno, Luisa Z
Kremer, Frederico S
Miraglia, Fabiana
Loureiro, Ana P
Eslabao, Marcus R
Dellagostin, Odir A
Lilenbaum, Walter
Moreno, Andrea M
author_sort Moreno, Luisa Z
collection PubMed
description Leptospira kirschneri is one of the pathogenic species of the Leptospira genus. Human and animal infection from L. kirschneri gained further attention over the last few decades. Here we present the isolation and characterisation of Brazilian L. kirschneri serogroup Pomona serovar Mozdok strain M36/05 and the comparative genomic analysis with Brazilian human strain 61H. The M36/05 strain caused pulmonary hemorrhagic lesions in the hamster model, showing high virulence. The studied genomes presented high symmetrical identity and the in silico multilocus sequence typing analysis resulted in a new allelic profile (ST101) that so far has only been associated with the Brazilian L. kirschneri serogroup Pomona serovar Mozdok strains. Considering the environmental conditions and high genomic similarity observed between strains, we suggest the existence of a Brazilian L. kirschneri serogroup Pomona serovar Mozdok lineage that could represent a high public health risk; further studies are necessary to confirm the lineage significance and distribution.
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spelling pubmed-49811182016-08-12 Comparative genomic analysis of Brazilian Leptospira kirschneri serogroup Pomona serovar Mozdok Moreno, Luisa Z Kremer, Frederico S Miraglia, Fabiana Loureiro, Ana P Eslabao, Marcus R Dellagostin, Odir A Lilenbaum, Walter Moreno, Andrea M Mem Inst Oswaldo Cruz Short Communication Leptospira kirschneri is one of the pathogenic species of the Leptospira genus. Human and animal infection from L. kirschneri gained further attention over the last few decades. Here we present the isolation and characterisation of Brazilian L. kirschneri serogroup Pomona serovar Mozdok strain M36/05 and the comparative genomic analysis with Brazilian human strain 61H. The M36/05 strain caused pulmonary hemorrhagic lesions in the hamster model, showing high virulence. The studied genomes presented high symmetrical identity and the in silico multilocus sequence typing analysis resulted in a new allelic profile (ST101) that so far has only been associated with the Brazilian L. kirschneri serogroup Pomona serovar Mozdok strains. Considering the environmental conditions and high genomic similarity observed between strains, we suggest the existence of a Brazilian L. kirschneri serogroup Pomona serovar Mozdok lineage that could represent a high public health risk; further studies are necessary to confirm the lineage significance and distribution. Instituto Oswaldo Cruz, Ministério da Saúde 2016-07-11 2016-08 /pmc/articles/PMC4981118/ /pubmed/27581124 http://dx.doi.org/10.1590/0074-02760160174 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Moreno, Luisa Z
Kremer, Frederico S
Miraglia, Fabiana
Loureiro, Ana P
Eslabao, Marcus R
Dellagostin, Odir A
Lilenbaum, Walter
Moreno, Andrea M
Comparative genomic analysis of Brazilian Leptospira kirschneri serogroup Pomona serovar Mozdok
title Comparative genomic analysis of Brazilian Leptospira kirschneri serogroup Pomona serovar Mozdok
title_full Comparative genomic analysis of Brazilian Leptospira kirschneri serogroup Pomona serovar Mozdok
title_fullStr Comparative genomic analysis of Brazilian Leptospira kirschneri serogroup Pomona serovar Mozdok
title_full_unstemmed Comparative genomic analysis of Brazilian Leptospira kirschneri serogroup Pomona serovar Mozdok
title_short Comparative genomic analysis of Brazilian Leptospira kirschneri serogroup Pomona serovar Mozdok
title_sort comparative genomic analysis of brazilian leptospira kirschneri serogroup pomona serovar mozdok
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981118/
https://www.ncbi.nlm.nih.gov/pubmed/27581124
http://dx.doi.org/10.1590/0074-02760160174
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