TDP-43 and ubiquitinated cytoplasmic aggregates in sporadic ALS are low frequency and widely distributed in the lower motor neuron columns independent of disease spread

Ubiqitinated and TDP-43 immunoreactive cytoplasmic aggregates are hallmark features of ALS molecular pathology. Since clinically most ALS begins focally and advances contiguously, it is important to characterize their distribution. Our objective was to determine the extent and distribution of TDP-43...

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Detalles Bibliográficos
Autores principales: Bodansky, Aaron, Kim, Jae Mun ‘Hugo’, Tempest, Lynne, Velagapudi, Amit, Libby, Ryan, Ravits, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981144/
https://www.ncbi.nlm.nih.gov/pubmed/20225928
http://dx.doi.org/10.3109/17482961003602363

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