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The development of an online database for interventions tested in transgenic mouse models of Alzheimer's disease
Despite many efforts by the research community, Alzheimer's disease (AD) is still an incurable neurodegenerative condition that affects an estimated 44 million individuals worldwide and this figure is expected to increase to 135 million by the year 2050. As the research community currently refl...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981146/ https://www.ncbi.nlm.nih.gov/pubmed/27570629 http://dx.doi.org/10.1002/ebm2.10 |
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author | Egan, K. J. Vesterinen, H. M. McCann, S. K. Sena, E. S. MacLeod, M. R. |
author_facet | Egan, K. J. Vesterinen, H. M. McCann, S. K. Sena, E. S. MacLeod, M. R. |
author_sort | Egan, K. J. |
collection | PubMed |
description | Despite many efforts by the research community, Alzheimer's disease (AD) is still an incurable neurodegenerative condition that affects an estimated 44 million individuals worldwide and this figure is expected to increase to 135 million by the year 2050. As the research community currently reflects on previous endeavours, it is essential that we maximize the use of existing knowledge to inform future trials in the field. This article describes the development of a systematically identified data set relating to over 300 interventions tested in over 10,000 animals. The data set includes cohort‐level information for six structural outcomes and six behavioural assessments. We encourage others to use this dataset to inform the design of future animal experiments modelling AD and to promote effective translation to human health. |
format | Online Article Text |
id | pubmed-4981146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-49811462016-08-24 The development of an online database for interventions tested in transgenic mouse models of Alzheimer's disease Egan, K. J. Vesterinen, H. M. McCann, S. K. Sena, E. S. MacLeod, M. R. Evid Based Preclin Med Data Articles Despite many efforts by the research community, Alzheimer's disease (AD) is still an incurable neurodegenerative condition that affects an estimated 44 million individuals worldwide and this figure is expected to increase to 135 million by the year 2050. As the research community currently reflects on previous endeavours, it is essential that we maximize the use of existing knowledge to inform future trials in the field. This article describes the development of a systematically identified data set relating to over 300 interventions tested in over 10,000 animals. The data set includes cohort‐level information for six structural outcomes and six behavioural assessments. We encourage others to use this dataset to inform the design of future animal experiments modelling AD and to promote effective translation to human health. John Wiley and Sons Inc. 2015-08 2015-08-11 /pmc/articles/PMC4981146/ /pubmed/27570629 http://dx.doi.org/10.1002/ebm2.10 Text en © 2015 The Authors. Evidence‐based Preclinical Medicine Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Data Articles Egan, K. J. Vesterinen, H. M. McCann, S. K. Sena, E. S. MacLeod, M. R. The development of an online database for interventions tested in transgenic mouse models of Alzheimer's disease |
title | The development of an online database for interventions tested in transgenic mouse models of Alzheimer's disease |
title_full | The development of an online database for interventions tested in transgenic mouse models of Alzheimer's disease |
title_fullStr | The development of an online database for interventions tested in transgenic mouse models of Alzheimer's disease |
title_full_unstemmed | The development of an online database for interventions tested in transgenic mouse models of Alzheimer's disease |
title_short | The development of an online database for interventions tested in transgenic mouse models of Alzheimer's disease |
title_sort | development of an online database for interventions tested in transgenic mouse models of alzheimer's disease |
topic | Data Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981146/ https://www.ncbi.nlm.nih.gov/pubmed/27570629 http://dx.doi.org/10.1002/ebm2.10 |
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