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The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy

Carbonic anhydrase IX (CAIX) is a tumor-specific protein that is upregulated during hypoxic conditions where it is involved in maintaining the pH balance. CAIX causes extracellular acidification, thereby limiting the uptake of weak basic chemotherapeutic agents, such as doxorubicin, and decreasing i...

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Detalles Bibliográficos
Autores principales:	van Kuijk, Simon J. A., Gieling, Roben G., Niemans, Raymon, Lieuwes, Natasja G., Biemans, Rianne, Telfer, Brian A., Haenen, Guido R. M. M., Yaromina, Ala, Lambin, Philippe, Dubois, Ludwig J., Williams, Kaye J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981362/ https://www.ncbi.nlm.nih.gov/pubmed/27513947 http://dx.doi.org/10.1371/journal.pone.0161040

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