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Micro-CT Imaging Reveals Mekk3 Heterozygosity Prevents Cerebral Cavernous Malformations in Ccm2-Deficient Mice

Mutations in CCM1 (aka KRIT1), CCM2, or CCM3 (aka PDCD10) gene cause cerebral cavernous malformation in humans. Mouse models of CCM disease have been established by deleting Ccm genes in postnatal animals. These mouse models provide invaluable tools to investigate molecular mechanism and therapeutic...

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Detalles Bibliográficos
Autores principales:	Choi, Jaesung P., Foley, Matthew, Zhou, Zinan, Wong, Weng-Yew, Gokoolparsadh, Naveena, Arthur, J. Simon C., Li, Dean Y., Zheng, Xiangjian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981389/ https://www.ncbi.nlm.nih.gov/pubmed/27513872 http://dx.doi.org/10.1371/journal.pone.0160833

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