Cargando…

Gads (Grb2-related adaptor downstream of Shc) is required for BCR-ABL-mediated lymphoid leukemia

Philadelphia chromosome-positive leukemias, including chronic myeloid leukemia and B-cell acute lymphoblastic leukemia (B-ALL), are driven by the oncogenic BCR-ABL fusion protein. Animal modeling experiments utilizing retroviral transduction and subsequent bone marrow transplantation have demonstrat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gillis, LC, Berry, DM, Minden, MD, McGlade, CJ, Barber, DL
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981500/ https://www.ncbi.nlm.nih.gov/pubmed/23399893 http://dx.doi.org/10.1038/leu.2013.40

Ejemplares similares

Coupling between p210bcr-abl and Shc and Grb2 adaptor proteins in hematopoietic cells permits growth factor receptor-independent link to ras activation pathway
Publicado: (1994)

Targeting BCR-ABL(+) stem/progenitor cells and BCR-ABL-T315I mutant cells by effective inhibition of the BCR-ABL-Tyr177-GRB2 complex
por: Chen, Min, et al.
Publicado: (2017)

Bridging the Gap: Modulatory Roles of the Grb2-Family Adaptor, Gads, in Cellular and Allergic Immune Responses
por: Yablonski, Deborah
Publicado: (2019)

The structural basis of BCR-ABL recruitment of GRB2 in chronic myelogenous leukemia
por: Liu, Yonglan, et al.
Publicado: (2022)

Brain-derived neurotrophic factor modulation of Kv1.3 channel is disregulated by adaptor proteins Grb10 and nShc
por: Colley, Beverly S, et al.
Publicado: (2009)

The neuronal Shc adaptor in Alzheimer’s Disease
por: Triaca, Viviana, et al.
Publicado: (2018)

Insights into the Shc Family of Adaptor Proteins
por: Ahmed, Samrein B. M., et al.
Publicado: (2017)

Recruitment of the Adaptor Protein Grb2 to EGFR Tetramers
por: Kozer, Noga, et al.
Publicado: (2014)

Localization of phosphotyrosine adaptor protein ShcD/SHC4 in the adult rat central nervous system
por: Robeson, Hannah N., et al.
Publicado: (2019)

Metabolic convergence on lipogenesis in RAS, BCR-ABL, and MYC-driven lymphoid malignancies
por: Liefwalker, Daniel F., et al.
Publicado: (2021)

Bifurcation of Cell Migratory and Proliferative Signaling by the Adaptor Protein Shc
por: Collins, Lila R., et al.
Publicado: (1999)

Regulation of microRNA expression by the adaptor protein GRB2
por: Stainthorp, Amy K., et al.
Publicado: (2023)

Involvement of Lat, Gads, and Grb2 in Compartmentation of Slp-76 to the Plasma Membrane
por: Ishiai, Masamichi, et al.
Publicado: (2000)

Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cells
por: Modi, Hardik, et al.
Publicado: (2010)

Biphasic spatiotemporal regulation of GRB2 dynamics by p52SHC for transient RAS activation
por: Yoshizawa, Ryo, et al.
Publicado: (2021)

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2
por: HUGHES, C E, et al.
Publicado: (2008)

Structural Basis for the Interaction of the Adaptor Protein Grb14 with Activated Ras
por: Qamra, Rohini, et al.
Publicado: (2013)

The Adaptor Protein Grb2 Is Not Essential for the Establishment of the Glomerular Filtration Barrier
por: Bisson, Nicolas, et al.
Publicado: (2012)

Pan-Cancer Study of SHC-Adaptor Protein 1 (SHC1) as a Diagnostic, Prognostic and Immunological Biomarker in Human Cancer
por: Chen, Jianlin, et al.
Publicado: (2022)

A BCR-ABL Mutant Lacking Direct Binding Sites for the GRB2, CBL and CRKL Adapter Proteins Fails to Induce Leukemia in Mice
por: Johnson, Kara J., et al.
Publicado: (2009)

Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I
por: Mian, Afsar Ali, et al.
Publicado: (2012)

The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor
por: Wills, Melanie K. B., et al.
Publicado: (2014)

Transcriptomic classes of BCR-ABL1 lymphoblastic leukemia
por: Kim, Jaeseung C., et al.
Publicado: (2023)

Stimulation of the catalytic activity of the tyrosine kinase Btk by the adaptor protein Grb2
por: Nocka, Laura M, et al.
Publicado: (2023)

The oxidative stress adaptor p66Shc is required for permanent embryo arrest in vitro
por: Favetta, Laura A, et al.
Publicado: (2007)

Modulation of Obesity and Insulin Resistance by the Redox Enzyme and Adaptor Protein p66(Shc)
por: Ciciliot, Stefano, et al.
Publicado: (2019)

Functional maintenance of calcium store by ShcB adaptor protein in cerebellar Purkinje cells
por: Kakizawa, Sho, et al.
Publicado: (2020)

Regulation of Selective B Cell Autophagy by the Pro-oxidant Adaptor p66SHC
por: Onnis, Anna, et al.
Publicado: (2020)

BCR/ABL1 and BCR are under the transcriptional control of the MYC oncogene
por: Sharma, Nitesh, et al.
Publicado: (2015)

Pterostilbene downregulates BCR/ABL and induces apoptosis of T315I-mutated BCR/ABL-positive leukemic cells
por: Kawakami, Shohei, et al.
Publicado: (2022)

The p66(Shc) Adaptor Protein Controls Oxidative Stress Response in Early Bovine Embryos
por: Betts, Dean H., et al.
Publicado: (2014)

Involvement of the neuronal phosphotyrosine signal adaptor N-Shc in kainic acid-induced epileptiform activity
por: Baba, Shiro, et al.
Publicado: (2016)

BCR: a new target in resistance mediated by BCR/ABL-315I?
por: Haberbosch, Isabella, et al.
Publicado: (2016)

Genomic amplification of BCR/ABL1 and a region downstream of ABL1 in chronic myeloid leukaemia: a FISH mapping study of CML patients and cell lines
por: Virgili, Anna, et al.
Publicado: (2010)

The novel anticancer agent JNJ-26854165 is active in chronic myeloid leukemic cells with unmutated BCR/ABL and T315I mutant BCR/ABL through promoting proteosomal degradation of BCR/ABL proteins
por: You, Liangshun, et al.
Publicado: (2016)

Chronic myeloid leukemia with an e1a3 BCR-ABL fusion protein: transformation to lymphoid blast crisis
por: Martinez-Serra, Jordi, et al.
Publicado: (2014)

Expanding the Diversity of Allosteric Bcr-Abl Inhibitors
por: Deng, Xianming, et al.
Publicado: (2010)

An In-House Method for Molecular Monitoring of BCR-ABL
por: Sercan, Hakkı Ogün, et al.
Publicado: (2012)

Depression of oncogenecity by dephosphorylating and degrading BCR-ABL
por: Gao, Miao, et al.
Publicado: (2016)

AHI-1 interacts with BCR-ABL and modulates BCR-ABL transforming activity and imatinib response of CML stem/progenitor cells
por: Zhou, Liang L., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_hsrs09bpoethvokqa3qfnrrs4v