Identification of Multiple Cryptococcal Fungicidal Drug Targets by Combined Gene Dosing and Drug Affinity Responsive Target Stability Screening

Cryptococcus neoformans is a pathogenic fungus that is responsible for up to half a million cases of meningitis globally, especially in immunocompromised individuals. Common fungistatic drugs, such as fluconazole, are less toxic for patients but have low efficacy for initial therapy of the disease....

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Detalles Bibliográficos
Autores principales: Park, Yoon-Dong, Sun, Wei, Salas, Antonio, Antia, Avan, Carvajal, Cindy, Wang, Amy, Xu, Xin, Meng, Zhaojin, Zhou, Ming, Tawa, Gregory J., Dehdashti, Jean, Zheng, Wei, Henderson, Christina M., Zelazny, Adrian M., Williamson, Peter R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981720/
https://www.ncbi.nlm.nih.gov/pubmed/27486194
http://dx.doi.org/10.1128/mBio.01073-16

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