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Glycomics for Microbes and Microbiologists

The recent article “Lectin-Glycan Interaction Network-Based Identification of Host Receptors of Microbial Pathogenic Adhesins” by Ielasi et al. describes a new development in microbial carbohydrate analysis [Ielasi FS, Alioscha-Perez M, Donohue D, Claes S, Sahli H, Schols D, Willaert RG, mBio 7(4):e...

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Detalles Bibliográficos
Autor principal: Lipke, Peter N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981726/
https://www.ncbi.nlm.nih.gov/pubmed/27507827
http://dx.doi.org/10.1128/mBio.01224-16
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author Lipke, Peter N.
author_facet Lipke, Peter N.
author_sort Lipke, Peter N.
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description The recent article “Lectin-Glycan Interaction Network-Based Identification of Host Receptors of Microbial Pathogenic Adhesins” by Ielasi et al. describes a new development in microbial carbohydrate analysis [Ielasi FS, Alioscha-Perez M, Donohue D, Claes S, Sahli H, Schols D, Willaert RG, mBio 7(4):e00584-16, 2016, http://dx.doi.org/10.1128/mbio.00584-16]. Specific carbohydrate ligands have been identified from the patterns of lectin binding to oligosaccharides printed on a chip. The new technique links the output to a comprehensive glycan database and offers a number of data visualization options. The graphs highlight the occurrence of potential ligands, organized by organism, tissue, and patterns of association with disease states. The analysis has successfully predicted novel glycoprotein ligands for microbial lectins, including an interaction of E. coli FimH with HIV gp120.
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spelling pubmed-49817262016-08-17 Glycomics for Microbes and Microbiologists Lipke, Peter N. mBio Commentary The recent article “Lectin-Glycan Interaction Network-Based Identification of Host Receptors of Microbial Pathogenic Adhesins” by Ielasi et al. describes a new development in microbial carbohydrate analysis [Ielasi FS, Alioscha-Perez M, Donohue D, Claes S, Sahli H, Schols D, Willaert RG, mBio 7(4):e00584-16, 2016, http://dx.doi.org/10.1128/mbio.00584-16]. Specific carbohydrate ligands have been identified from the patterns of lectin binding to oligosaccharides printed on a chip. The new technique links the output to a comprehensive glycan database and offers a number of data visualization options. The graphs highlight the occurrence of potential ligands, organized by organism, tissue, and patterns of association with disease states. The analysis has successfully predicted novel glycoprotein ligands for microbial lectins, including an interaction of E. coli FimH with HIV gp120. American Society for Microbiology 2016-08-09 /pmc/articles/PMC4981726/ /pubmed/27507827 http://dx.doi.org/10.1128/mBio.01224-16 Text en Copyright © 2016 Lipke. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Commentary
Lipke, Peter N.
Glycomics for Microbes and Microbiologists
title Glycomics for Microbes and Microbiologists
title_full Glycomics for Microbes and Microbiologists
title_fullStr Glycomics for Microbes and Microbiologists
title_full_unstemmed Glycomics for Microbes and Microbiologists
title_short Glycomics for Microbes and Microbiologists
title_sort glycomics for microbes and microbiologists
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981726/
https://www.ncbi.nlm.nih.gov/pubmed/27507827
http://dx.doi.org/10.1128/mBio.01224-16
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