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Nutraceuticals against Neurodegeneration: A Mechanistic Insight
The mechanisms underlying neurodegenerative disorders are complex and multifactorial; however, accumulating evidences suggest few common shared pathways. These common pathways include mitochondrial dysfunction, intracellular Ca(2+) overload, oxidative stress and inflammation. Often multiple pathways...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981739/ https://www.ncbi.nlm.nih.gov/pubmed/26725888 http://dx.doi.org/10.2174/1570159X14666160104142223 |
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author | Dadhania, Vivekkumar P. Trivedi, Priyanka P. Vikram, Ajit Tripathi, Durga Nand |
author_facet | Dadhania, Vivekkumar P. Trivedi, Priyanka P. Vikram, Ajit Tripathi, Durga Nand |
author_sort | Dadhania, Vivekkumar P. |
collection | PubMed |
description | The mechanisms underlying neurodegenerative disorders are complex and multifactorial; however, accumulating evidences suggest few common shared pathways. These common pathways include mitochondrial dysfunction, intracellular Ca(2+) overload, oxidative stress and inflammation. Often multiple pathways co-exist, and therefore limit the benefits of therapeutic interventions. Nutraceuticals have recently gained importance owing to their multifaceted effects. These food-based approaches are believed to target multiple pathways in a slow but more physiological manner without causing severe adverse effects. Available information strongly supports the notion that apart from preventing the onset of neuronal damage, nutraceuticals can potentially attenuate the continued progression of neuronal destruction. In this article, we i) review the common pathways involved in the pathogenesis of the toxicants-induced neurotoxicity and neurodegenerative disorders with special emphasis on Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Multiple sclerosis (MS) and Amyotrophic lateral sclerosis (ALS), and ii) summarize current research advancements on the effects of nutraceuticals against these detrimental pathways. |
format | Online Article Text |
id | pubmed-4981739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-49817392017-02-01 Nutraceuticals against Neurodegeneration: A Mechanistic Insight Dadhania, Vivekkumar P. Trivedi, Priyanka P. Vikram, Ajit Tripathi, Durga Nand Curr Neuropharmacol Article The mechanisms underlying neurodegenerative disorders are complex and multifactorial; however, accumulating evidences suggest few common shared pathways. These common pathways include mitochondrial dysfunction, intracellular Ca(2+) overload, oxidative stress and inflammation. Often multiple pathways co-exist, and therefore limit the benefits of therapeutic interventions. Nutraceuticals have recently gained importance owing to their multifaceted effects. These food-based approaches are believed to target multiple pathways in a slow but more physiological manner without causing severe adverse effects. Available information strongly supports the notion that apart from preventing the onset of neuronal damage, nutraceuticals can potentially attenuate the continued progression of neuronal destruction. In this article, we i) review the common pathways involved in the pathogenesis of the toxicants-induced neurotoxicity and neurodegenerative disorders with special emphasis on Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Multiple sclerosis (MS) and Amyotrophic lateral sclerosis (ALS), and ii) summarize current research advancements on the effects of nutraceuticals against these detrimental pathways. Bentham Science Publishers 2016-08 2016-08 /pmc/articles/PMC4981739/ /pubmed/26725888 http://dx.doi.org/10.2174/1570159X14666160104142223 Text en © 2016 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Dadhania, Vivekkumar P. Trivedi, Priyanka P. Vikram, Ajit Tripathi, Durga Nand Nutraceuticals against Neurodegeneration: A Mechanistic Insight |
title | Nutraceuticals against Neurodegeneration: A Mechanistic Insight |
title_full | Nutraceuticals against Neurodegeneration: A Mechanistic Insight |
title_fullStr | Nutraceuticals against Neurodegeneration: A Mechanistic Insight |
title_full_unstemmed | Nutraceuticals against Neurodegeneration: A Mechanistic Insight |
title_short | Nutraceuticals against Neurodegeneration: A Mechanistic Insight |
title_sort | nutraceuticals against neurodegeneration: a mechanistic insight |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981739/ https://www.ncbi.nlm.nih.gov/pubmed/26725888 http://dx.doi.org/10.2174/1570159X14666160104142223 |
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