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Cognitive Impairment Associated with Parkinson’s Disease: Role of Mitochondria

Parkinson’s disease (PD) is a movement disorder and is associated with some of the intellectual disabilities like cognitive dysfunctions. PD associated cognitive dysfunctions have been proved well in both preclinical and clinical set ups. Like other neurodegenerative diseases, insults to mitochondri...

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Autores principales: Das, Nihar R., Sharma, Shyam S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981741/
https://www.ncbi.nlm.nih.gov/pubmed/26725887
http://dx.doi.org/10.2174/1570159X14666160104142349
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author Das, Nihar R.
Sharma, Shyam S.
author_facet Das, Nihar R.
Sharma, Shyam S.
author_sort Das, Nihar R.
collection PubMed
description Parkinson’s disease (PD) is a movement disorder and is associated with some of the intellectual disabilities like cognitive dysfunctions. PD associated cognitive dysfunctions have been proved well in both preclinical and clinical set ups. Like other neurodegenerative diseases, insults to mitochondria have a significant role in the pathobiology of PD associated dementia (PDD). Neurotoxins like MPTP, mutations of the mitochondrial genes, oxidative stress, imbalanced redox mechanisms and dysregulated mitochondrial dynamics have been implicated in mitochondrial dysfunctions and have paramount importance in the pathobiology of PDD. However, the extent of contribution of mitochondrial dysfunctions towards cognitive deficits in PD has not been characterized completely. In this review we highlight on the contribution of mitochondrial dysfunction to PDD. We also highlight different behavioural tests used in nonhuman primate and rodent models for assessing cognitive deficits and some common techniques for evaluation of mitochondrial dysfunction in PDD.
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spelling pubmed-49817412017-02-01 Cognitive Impairment Associated with Parkinson’s Disease: Role of Mitochondria Das, Nihar R. Sharma, Shyam S. Curr Neuropharmacol Article Parkinson’s disease (PD) is a movement disorder and is associated with some of the intellectual disabilities like cognitive dysfunctions. PD associated cognitive dysfunctions have been proved well in both preclinical and clinical set ups. Like other neurodegenerative diseases, insults to mitochondria have a significant role in the pathobiology of PD associated dementia (PDD). Neurotoxins like MPTP, mutations of the mitochondrial genes, oxidative stress, imbalanced redox mechanisms and dysregulated mitochondrial dynamics have been implicated in mitochondrial dysfunctions and have paramount importance in the pathobiology of PDD. However, the extent of contribution of mitochondrial dysfunctions towards cognitive deficits in PD has not been characterized completely. In this review we highlight on the contribution of mitochondrial dysfunction to PDD. We also highlight different behavioural tests used in nonhuman primate and rodent models for assessing cognitive deficits and some common techniques for evaluation of mitochondrial dysfunction in PDD. Bentham Science Publishers 2016-08 2016-08 /pmc/articles/PMC4981741/ /pubmed/26725887 http://dx.doi.org/10.2174/1570159X14666160104142349 Text en © 2016 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Das, Nihar R.
Sharma, Shyam S.
Cognitive Impairment Associated with Parkinson’s Disease: Role of Mitochondria
title Cognitive Impairment Associated with Parkinson’s Disease: Role of Mitochondria
title_full Cognitive Impairment Associated with Parkinson’s Disease: Role of Mitochondria
title_fullStr Cognitive Impairment Associated with Parkinson’s Disease: Role of Mitochondria
title_full_unstemmed Cognitive Impairment Associated with Parkinson’s Disease: Role of Mitochondria
title_short Cognitive Impairment Associated with Parkinson’s Disease: Role of Mitochondria
title_sort cognitive impairment associated with parkinson’s disease: role of mitochondria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981741/
https://www.ncbi.nlm.nih.gov/pubmed/26725887
http://dx.doi.org/10.2174/1570159X14666160104142349
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