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ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing

The processing of MHC class I antigenic precursor peptides by the endoplasmic reticulum aminopeptidase 1 (ERAP1) and ERAP2 is an important event in the cell biology of antigen presentation. To date, the molecular context by which the ERAP enzymes trim precursor peptides, and how ERAPs shape peptide...

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Detalles Bibliográficos
Autores principales:	Chen, Hanna, Li, Lenong, Weimershaus, Mirjana, Evnouchidou, Irini, van Endert, Peter, Bouvier, Marlene
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981824/ https://www.ncbi.nlm.nih.gov/pubmed/27514473 http://dx.doi.org/10.1038/srep28902

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