Aβ Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival

The E3 ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C) is activated by the fizzy-related protein homolog/CDC20-like protein 1 (cdh1) in post-mitotic neurons. Growing evidence suggests that dysregulation of APC/C-Cdh1 is involved in neurodegenerative diseases. Here we show in neurons th...

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Detalles Bibliográficos
Autores principales: Fuchsberger, T., Martínez-Bellver, S., Giraldo, E., Teruel-Martí, V., Lloret, A., Viña, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981891/
https://www.ncbi.nlm.nih.gov/pubmed/27514492
http://dx.doi.org/10.1038/srep31158

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