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A case of ovarian adenosquamous carcinoma arising from endometrioid adenocarcinoma: a case report and systematic review

BACKGROUND: The aims of this report were to describe a case of ovarian adenosquamous carcinoma and to systematically review the pertinent literature. METHODS: We describe a case in which a 57-year-old woman had stage IC ovarian cancer histologically diagnosed as adenosquamous carcinoma. We also syst...

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Autores principales: Shoji, Tadahiro, Takatori, Eriko, Murakami, Kazuyuki, Kaido, Yoshitaka, Takeuchi, Satoshi, Kikuchi, Akihiko, Sugiyama, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981951/
https://www.ncbi.nlm.nih.gov/pubmed/27514842
http://dx.doi.org/10.1186/s13048-016-0255-6
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author Shoji, Tadahiro
Takatori, Eriko
Murakami, Kazuyuki
Kaido, Yoshitaka
Takeuchi, Satoshi
Kikuchi, Akihiko
Sugiyama, Toru
author_facet Shoji, Tadahiro
Takatori, Eriko
Murakami, Kazuyuki
Kaido, Yoshitaka
Takeuchi, Satoshi
Kikuchi, Akihiko
Sugiyama, Toru
author_sort Shoji, Tadahiro
collection PubMed
description BACKGROUND: The aims of this report were to describe a case of ovarian adenosquamous carcinoma and to systematically review the pertinent literature. METHODS: We describe a case in which a 57-year-old woman had stage IC ovarian cancer histologically diagnosed as adenosquamous carcinoma. We also systematically reviewed the literature using the PubMed database. CASE PRESENTATION: Preoperative computed tomography and magnetic resonance imaging showed a tumor measuring 14 cm in diameter and containing solid areas. Tumor marker levels were as follows: CA125, 42.6 U/mL; CA 19–9, 134.1 U/mL; CEA, 0.9 ng/mL; and SCC, 1.6 ng/mL. The patient underwent multiple surgeries including total abdominal hysterectomy, bilateral salpingo-oophorectomy, pelvic lymph node dissection, para-aortic lymph node biopsy, and total omentectomy. Based on the cytological features of the ascitic fluid, the tumor was diagnosed as a squamous cell carcinoma. Histological examination of an excised specimen showed the transition of an endometrioid adenocarcinoma to a squamous cell carcinoma. There was no evidence of any teratomas or endometriosis-related features. We considered the tumor to be an adenosquamous carcinoma, with the squamous cell carcinoma component arising from the endometrioid adenocarcinoma component. After surgery, the patient underwent 6 cycles of paclitaxel and carboplatin chemotherapy. There has been no recurrence to date, 66 months after the initial treatment. RESULTS: Histologically, the 8 adenosquamous carcinomas reported in the literature either arose from the mature cystic teratoma (4 cases) or endometriosis (3 cases) or were pure adenosquamous carcinomas (1 case). Our literature search uncovered no cases of ovarian adenosquamous carcinomas originating from endometrioid adenocarcinomas. CONCLUSIONS: This is the first reported case of an adenosquamous carcinoma arising from an endometrioid adenocarcinoma. Because such tumors are rare, their standard management is unclear.
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spelling pubmed-49819512016-08-13 A case of ovarian adenosquamous carcinoma arising from endometrioid adenocarcinoma: a case report and systematic review Shoji, Tadahiro Takatori, Eriko Murakami, Kazuyuki Kaido, Yoshitaka Takeuchi, Satoshi Kikuchi, Akihiko Sugiyama, Toru J Ovarian Res Case Report BACKGROUND: The aims of this report were to describe a case of ovarian adenosquamous carcinoma and to systematically review the pertinent literature. METHODS: We describe a case in which a 57-year-old woman had stage IC ovarian cancer histologically diagnosed as adenosquamous carcinoma. We also systematically reviewed the literature using the PubMed database. CASE PRESENTATION: Preoperative computed tomography and magnetic resonance imaging showed a tumor measuring 14 cm in diameter and containing solid areas. Tumor marker levels were as follows: CA125, 42.6 U/mL; CA 19–9, 134.1 U/mL; CEA, 0.9 ng/mL; and SCC, 1.6 ng/mL. The patient underwent multiple surgeries including total abdominal hysterectomy, bilateral salpingo-oophorectomy, pelvic lymph node dissection, para-aortic lymph node biopsy, and total omentectomy. Based on the cytological features of the ascitic fluid, the tumor was diagnosed as a squamous cell carcinoma. Histological examination of an excised specimen showed the transition of an endometrioid adenocarcinoma to a squamous cell carcinoma. There was no evidence of any teratomas or endometriosis-related features. We considered the tumor to be an adenosquamous carcinoma, with the squamous cell carcinoma component arising from the endometrioid adenocarcinoma component. After surgery, the patient underwent 6 cycles of paclitaxel and carboplatin chemotherapy. There has been no recurrence to date, 66 months after the initial treatment. RESULTS: Histologically, the 8 adenosquamous carcinomas reported in the literature either arose from the mature cystic teratoma (4 cases) or endometriosis (3 cases) or were pure adenosquamous carcinomas (1 case). Our literature search uncovered no cases of ovarian adenosquamous carcinomas originating from endometrioid adenocarcinomas. CONCLUSIONS: This is the first reported case of an adenosquamous carcinoma arising from an endometrioid adenocarcinoma. Because such tumors are rare, their standard management is unclear. BioMed Central 2016-08-11 /pmc/articles/PMC4981951/ /pubmed/27514842 http://dx.doi.org/10.1186/s13048-016-0255-6 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Shoji, Tadahiro
Takatori, Eriko
Murakami, Kazuyuki
Kaido, Yoshitaka
Takeuchi, Satoshi
Kikuchi, Akihiko
Sugiyama, Toru
A case of ovarian adenosquamous carcinoma arising from endometrioid adenocarcinoma: a case report and systematic review
title A case of ovarian adenosquamous carcinoma arising from endometrioid adenocarcinoma: a case report and systematic review
title_full A case of ovarian adenosquamous carcinoma arising from endometrioid adenocarcinoma: a case report and systematic review
title_fullStr A case of ovarian adenosquamous carcinoma arising from endometrioid adenocarcinoma: a case report and systematic review
title_full_unstemmed A case of ovarian adenosquamous carcinoma arising from endometrioid adenocarcinoma: a case report and systematic review
title_short A case of ovarian adenosquamous carcinoma arising from endometrioid adenocarcinoma: a case report and systematic review
title_sort case of ovarian adenosquamous carcinoma arising from endometrioid adenocarcinoma: a case report and systematic review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981951/
https://www.ncbi.nlm.nih.gov/pubmed/27514842
http://dx.doi.org/10.1186/s13048-016-0255-6
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