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Hypoxia inducible factor-1 alpha and prolinhydroxlase 2 polymorphisms in patients with severe sepsis: a prospective observational trial

BACKGROUND: Hypoxia-inducible-factor-1α (HIF-1α) and HIF-1 degrading prolyl-hydroxylases (PHD) are key regulators of the hypoxic-inflammatory response. Functionally active genetic variants in the HIF-1α (C/T; Single Nucleotide Polymorphism (SNP) rs11549465) and the PHD2 gene (EGLN1; C/T; SNP rs51665...

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Detalles Bibliográficos
Autores principales:	Höcker, Annika, Rabeling, Miriam, Bick, Alexandra, Cox, Linda, Kreuzer, Maximiliane, Engler, Andrea, Walstein, Kai, Bachmann, Hagen S., Jöckel, Karl-Heinz, Eisele, Lewin, Adamzik, Michael, Peters, Jürgen, Schäfer, Simon T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982006/ https://www.ncbi.nlm.nih.gov/pubmed/27515179 http://dx.doi.org/10.1186/s12871-016-0225-y

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