AKT1(E17K) mutation profiling in breast cancer: prevalence, concurrent oncogenic alterations, and blood-based detection

BACKGROUND: The single hotspot mutation AKT1 [G49A:E17K] has been described in several cancers, with the highest incidence observed in breast cancer. However, its precise role in disease etiology remains unknown. METHODS: We analyzed more than 600 breast cancer tumor samples and circulating tumor DN...

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Detalles Bibliográficos
Autores principales: Rudolph, Marion, Anzeneder, Tobias, Schulz, Anke, Beckmann, Georg, Byrne, Annette T., Jeffers, Michael, Pena, Carol, Politz, Oliver, Köchert, Karl, Vonk, Richardus, Reischl, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982009/
https://www.ncbi.nlm.nih.gov/pubmed/27515171
http://dx.doi.org/10.1186/s12885-016-2626-1

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