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Synthetic redesign of plant lipid metabolism

Plant seed lipid metabolism is an area of intensive research, including many examples of transgenic events in which oil composition has been modified. In the selected examples described in this review, progress towards the predictive manipulation of metabolism and the reconstitution of desired trait...

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Autores principales: Haslam, Richard P., Sayanova, Olga, Kim, Hae Jin, Cahoon, Edgar B., Napier, Johnathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982047/
https://www.ncbi.nlm.nih.gov/pubmed/27483205
http://dx.doi.org/10.1111/tpj.13172
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author Haslam, Richard P.
Sayanova, Olga
Kim, Hae Jin
Cahoon, Edgar B.
Napier, Johnathan A.
author_facet Haslam, Richard P.
Sayanova, Olga
Kim, Hae Jin
Cahoon, Edgar B.
Napier, Johnathan A.
author_sort Haslam, Richard P.
collection PubMed
description Plant seed lipid metabolism is an area of intensive research, including many examples of transgenic events in which oil composition has been modified. In the selected examples described in this review, progress towards the predictive manipulation of metabolism and the reconstitution of desired traits in a non‐native host is considered. The advantages of a particular oilseed crop, Camelina sativa, as a flexible and utilitarian chassis for advanced metabolic engineering and applied synthetic biology are considered, as are the issues that still represent gaps in our ability to predictably alter plant lipid biosynthesis. Opportunities to deliver useful bio‐based products via transgenic plants are described, some of which represent the most complex genetic engineering in plants to date. Future prospects are considered, with a focus on the desire to transition to more (computationally) directed manipulations of metabolism.
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spelling pubmed-49820472016-08-24 Synthetic redesign of plant lipid metabolism Haslam, Richard P. Sayanova, Olga Kim, Hae Jin Cahoon, Edgar B. Napier, Johnathan A. Plant J Synthetic Biology for Basic and Applied Plant Research Plant seed lipid metabolism is an area of intensive research, including many examples of transgenic events in which oil composition has been modified. In the selected examples described in this review, progress towards the predictive manipulation of metabolism and the reconstitution of desired traits in a non‐native host is considered. The advantages of a particular oilseed crop, Camelina sativa, as a flexible and utilitarian chassis for advanced metabolic engineering and applied synthetic biology are considered, as are the issues that still represent gaps in our ability to predictably alter plant lipid biosynthesis. Opportunities to deliver useful bio‐based products via transgenic plants are described, some of which represent the most complex genetic engineering in plants to date. Future prospects are considered, with a focus on the desire to transition to more (computationally) directed manipulations of metabolism. John Wiley and Sons Inc. 2016-06-20 2016-07 /pmc/articles/PMC4982047/ /pubmed/27483205 http://dx.doi.org/10.1111/tpj.13172 Text en © 2016 The Authors. The Plant Journal published by Society for Experimental Biology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Synthetic Biology for Basic and Applied Plant Research
Haslam, Richard P.
Sayanova, Olga
Kim, Hae Jin
Cahoon, Edgar B.
Napier, Johnathan A.
Synthetic redesign of plant lipid metabolism
title Synthetic redesign of plant lipid metabolism
title_full Synthetic redesign of plant lipid metabolism
title_fullStr Synthetic redesign of plant lipid metabolism
title_full_unstemmed Synthetic redesign of plant lipid metabolism
title_short Synthetic redesign of plant lipid metabolism
title_sort synthetic redesign of plant lipid metabolism
topic Synthetic Biology for Basic and Applied Plant Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982047/
https://www.ncbi.nlm.nih.gov/pubmed/27483205
http://dx.doi.org/10.1111/tpj.13172
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