Os(2)–Os(4) Switch Controls DNA Knotting and Anticancer Activity

Dinuclear trihydroxido‐bridged osmium–arene complexes are inert and biologically inactive, but we show here that linking dihydroxido‐bridged Os(II)–arene fragments by a bridging di‐imine to form a metallacycle framework results in strong antiproliferative activity towards cancer cells and distinctiv...

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Detalles Bibliográficos
Autores principales: Fu, Ying, Romero, María J., Salassa, Luca, Cheng, Xi, Habtemariam, Abraha, Clarkson, Guy J., Prokes, Ivan, Rodger, Alison, Costantini, Giovanni, Sadler, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982093/
https://www.ncbi.nlm.nih.gov/pubmed/27240103
http://dx.doi.org/10.1002/anie.201602995
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author Fu, Ying
Romero, María J.
Salassa, Luca
Cheng, Xi
Habtemariam, Abraha
Clarkson, Guy J.
Prokes, Ivan
Rodger, Alison
Costantini, Giovanni
Sadler, Peter J.
author_facet Fu, Ying
Romero, María J.
Salassa, Luca
Cheng, Xi
Habtemariam, Abraha
Clarkson, Guy J.
Prokes, Ivan
Rodger, Alison
Costantini, Giovanni
Sadler, Peter J.
author_sort Fu, Ying
collection PubMed
description Dinuclear trihydroxido‐bridged osmium–arene complexes are inert and biologically inactive, but we show here that linking dihydroxido‐bridged Os(II)–arene fragments by a bridging di‐imine to form a metallacycle framework results in strong antiproliferative activity towards cancer cells and distinctive knotting of DNA. The shortened spacer length reduces biological activity and stability in solution towards decomposition to biologically inactive dimers. Significant differences in behavior toward plasmid DNA condensation are correlated with biological activity.
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spelling pubmed-49820932016-08-24 Os(2)–Os(4) Switch Controls DNA Knotting and Anticancer Activity Fu, Ying Romero, María J. Salassa, Luca Cheng, Xi Habtemariam, Abraha Clarkson, Guy J. Prokes, Ivan Rodger, Alison Costantini, Giovanni Sadler, Peter J. Angew Chem Int Ed Engl Communications Dinuclear trihydroxido‐bridged osmium–arene complexes are inert and biologically inactive, but we show here that linking dihydroxido‐bridged Os(II)–arene fragments by a bridging di‐imine to form a metallacycle framework results in strong antiproliferative activity towards cancer cells and distinctive knotting of DNA. The shortened spacer length reduces biological activity and stability in solution towards decomposition to biologically inactive dimers. Significant differences in behavior toward plasmid DNA condensation are correlated with biological activity. John Wiley and Sons Inc. 2016-05-30 2016-07-25 /pmc/articles/PMC4982093/ /pubmed/27240103 http://dx.doi.org/10.1002/anie.201602995 Text en © 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Fu, Ying
Romero, María J.
Salassa, Luca
Cheng, Xi
Habtemariam, Abraha
Clarkson, Guy J.
Prokes, Ivan
Rodger, Alison
Costantini, Giovanni
Sadler, Peter J.
Os(2)–Os(4) Switch Controls DNA Knotting and Anticancer Activity
title Os(2)–Os(4) Switch Controls DNA Knotting and Anticancer Activity
title_full Os(2)–Os(4) Switch Controls DNA Knotting and Anticancer Activity
title_fullStr Os(2)–Os(4) Switch Controls DNA Knotting and Anticancer Activity
title_full_unstemmed Os(2)–Os(4) Switch Controls DNA Knotting and Anticancer Activity
title_short Os(2)–Os(4) Switch Controls DNA Knotting and Anticancer Activity
title_sort os(2)–os(4) switch controls dna knotting and anticancer activity
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982093/
https://www.ncbi.nlm.nih.gov/pubmed/27240103
http://dx.doi.org/10.1002/anie.201602995
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