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Os(2)–Os(4) Switch Controls DNA Knotting and Anticancer Activity

Dinuclear trihydroxido‐bridged osmium–arene complexes are inert and biologically inactive, but we show here that linking dihydroxido‐bridged Os(II)–arene fragments by a bridging di‐imine to form a metallacycle framework results in strong antiproliferative activity towards cancer cells and distinctiv...

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Detalles Bibliográficos
Autores principales:	Fu, Ying, Romero, María J., Salassa, Luca, Cheng, Xi, Habtemariam, Abraha, Clarkson, Guy J., Prokes, Ivan, Rodger, Alison, Costantini, Giovanni, Sadler, Peter J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982093/ https://www.ncbi.nlm.nih.gov/pubmed/27240103 http://dx.doi.org/10.1002/anie.201602995

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