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Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014
Risk factors for human-to-human transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) are largely unknown. After MERS-CoV infections occurred in an extended family in Saudi Arabia in 2014, relatives were tested by using real-time reverse transcription PCR (rRT-PCR) and serologic me...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982159/ https://www.ncbi.nlm.nih.gov/pubmed/27191038 http://dx.doi.org/10.3201/eid2208.152015 |
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author | Arwady, M. Allison Alraddadi, Basem Basler, Colin Azhar, Esam I. Abuelzein, Eltayb Sindy, Abdulfattah I. Sadiq, Bakr M. Bin Althaqafi, Abdulhakeem O. Shabouni, Omaima Banjar, Ayman Haynes, Lia M. Gerber, Susan I. Feikin, Daniel R. Madani, Tariq A. |
author_facet | Arwady, M. Allison Alraddadi, Basem Basler, Colin Azhar, Esam I. Abuelzein, Eltayb Sindy, Abdulfattah I. Sadiq, Bakr M. Bin Althaqafi, Abdulhakeem O. Shabouni, Omaima Banjar, Ayman Haynes, Lia M. Gerber, Susan I. Feikin, Daniel R. Madani, Tariq A. |
author_sort | Arwady, M. Allison |
collection | PubMed |
description | Risk factors for human-to-human transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) are largely unknown. After MERS-CoV infections occurred in an extended family in Saudi Arabia in 2014, relatives were tested by using real-time reverse transcription PCR (rRT-PCR) and serologic methods. Among 79 relatives, 19 (24%) were MERS-CoV positive; 11 were hospitalized, and 2 died. Eleven (58%) tested positive by rRT-PCR; 8 (42%) tested negative by rRT-PCR but positive by serology. Compared with MERS-CoV–negative adult relatives, MERS-CoV–positive adult relatives were older and more likely to be male and to have chronic medical conditions. Risk factors for household transmission included sleeping in an index patient’s room and touching respiratory secretions from an index patient. Casual contact and simple proximity were not associated with transmission. Serology was more sensitive than standard rRT-PCR for identifying infected relatives, highlighting the value of including serology in future investigations. |
format | Online Article Text |
id | pubmed-4982159 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-49821592016-08-12 Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014 Arwady, M. Allison Alraddadi, Basem Basler, Colin Azhar, Esam I. Abuelzein, Eltayb Sindy, Abdulfattah I. Sadiq, Bakr M. Bin Althaqafi, Abdulhakeem O. Shabouni, Omaima Banjar, Ayman Haynes, Lia M. Gerber, Susan I. Feikin, Daniel R. Madani, Tariq A. Emerg Infect Dis Research Risk factors for human-to-human transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) are largely unknown. After MERS-CoV infections occurred in an extended family in Saudi Arabia in 2014, relatives were tested by using real-time reverse transcription PCR (rRT-PCR) and serologic methods. Among 79 relatives, 19 (24%) were MERS-CoV positive; 11 were hospitalized, and 2 died. Eleven (58%) tested positive by rRT-PCR; 8 (42%) tested negative by rRT-PCR but positive by serology. Compared with MERS-CoV–negative adult relatives, MERS-CoV–positive adult relatives were older and more likely to be male and to have chronic medical conditions. Risk factors for household transmission included sleeping in an index patient’s room and touching respiratory secretions from an index patient. Casual contact and simple proximity were not associated with transmission. Serology was more sensitive than standard rRT-PCR for identifying infected relatives, highlighting the value of including serology in future investigations. Centers for Disease Control and Prevention 2016-08 /pmc/articles/PMC4982159/ /pubmed/27191038 http://dx.doi.org/10.3201/eid2208.152015 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Arwady, M. Allison Alraddadi, Basem Basler, Colin Azhar, Esam I. Abuelzein, Eltayb Sindy, Abdulfattah I. Sadiq, Bakr M. Bin Althaqafi, Abdulhakeem O. Shabouni, Omaima Banjar, Ayman Haynes, Lia M. Gerber, Susan I. Feikin, Daniel R. Madani, Tariq A. Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014 |
title | Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014 |
title_full | Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014 |
title_fullStr | Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014 |
title_full_unstemmed | Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014 |
title_short | Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014 |
title_sort | middle east respiratory syndrome coronavirus transmission in extended family, saudi arabia, 2014 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982159/ https://www.ncbi.nlm.nih.gov/pubmed/27191038 http://dx.doi.org/10.3201/eid2208.152015 |
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