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Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014

Risk factors for human-to-human transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) are largely unknown. After MERS-CoV infections occurred in an extended family in Saudi Arabia in 2014, relatives were tested by using real-time reverse transcription PCR (rRT-PCR) and serologic me...

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Autores principales: Arwady, M. Allison, Alraddadi, Basem, Basler, Colin, Azhar, Esam I., Abuelzein, Eltayb, Sindy, Abdulfattah I., Sadiq, Bakr M. Bin, Althaqafi, Abdulhakeem O., Shabouni, Omaima, Banjar, Ayman, Haynes, Lia M., Gerber, Susan I., Feikin, Daniel R., Madani, Tariq A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982159/
https://www.ncbi.nlm.nih.gov/pubmed/27191038
http://dx.doi.org/10.3201/eid2208.152015
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author Arwady, M. Allison
Alraddadi, Basem
Basler, Colin
Azhar, Esam I.
Abuelzein, Eltayb
Sindy, Abdulfattah I.
Sadiq, Bakr M. Bin
Althaqafi, Abdulhakeem O.
Shabouni, Omaima
Banjar, Ayman
Haynes, Lia M.
Gerber, Susan I.
Feikin, Daniel R.
Madani, Tariq A.
author_facet Arwady, M. Allison
Alraddadi, Basem
Basler, Colin
Azhar, Esam I.
Abuelzein, Eltayb
Sindy, Abdulfattah I.
Sadiq, Bakr M. Bin
Althaqafi, Abdulhakeem O.
Shabouni, Omaima
Banjar, Ayman
Haynes, Lia M.
Gerber, Susan I.
Feikin, Daniel R.
Madani, Tariq A.
author_sort Arwady, M. Allison
collection PubMed
description Risk factors for human-to-human transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) are largely unknown. After MERS-CoV infections occurred in an extended family in Saudi Arabia in 2014, relatives were tested by using real-time reverse transcription PCR (rRT-PCR) and serologic methods. Among 79 relatives, 19 (24%) were MERS-CoV positive; 11 were hospitalized, and 2 died. Eleven (58%) tested positive by rRT-PCR; 8 (42%) tested negative by rRT-PCR but positive by serology. Compared with MERS-CoV–negative adult relatives, MERS-CoV–positive adult relatives were older and more likely to be male and to have chronic medical conditions. Risk factors for household transmission included sleeping in an index patient’s room and touching respiratory secretions from an index patient. Casual contact and simple proximity were not associated with transmission. Serology was more sensitive than standard rRT-PCR for identifying infected relatives, highlighting the value of including serology in future investigations.
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spelling pubmed-49821592016-08-12 Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014 Arwady, M. Allison Alraddadi, Basem Basler, Colin Azhar, Esam I. Abuelzein, Eltayb Sindy, Abdulfattah I. Sadiq, Bakr M. Bin Althaqafi, Abdulhakeem O. Shabouni, Omaima Banjar, Ayman Haynes, Lia M. Gerber, Susan I. Feikin, Daniel R. Madani, Tariq A. Emerg Infect Dis Research Risk factors for human-to-human transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) are largely unknown. After MERS-CoV infections occurred in an extended family in Saudi Arabia in 2014, relatives were tested by using real-time reverse transcription PCR (rRT-PCR) and serologic methods. Among 79 relatives, 19 (24%) were MERS-CoV positive; 11 were hospitalized, and 2 died. Eleven (58%) tested positive by rRT-PCR; 8 (42%) tested negative by rRT-PCR but positive by serology. Compared with MERS-CoV–negative adult relatives, MERS-CoV–positive adult relatives were older and more likely to be male and to have chronic medical conditions. Risk factors for household transmission included sleeping in an index patient’s room and touching respiratory secretions from an index patient. Casual contact and simple proximity were not associated with transmission. Serology was more sensitive than standard rRT-PCR for identifying infected relatives, highlighting the value of including serology in future investigations. Centers for Disease Control and Prevention 2016-08 /pmc/articles/PMC4982159/ /pubmed/27191038 http://dx.doi.org/10.3201/eid2208.152015 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Arwady, M. Allison
Alraddadi, Basem
Basler, Colin
Azhar, Esam I.
Abuelzein, Eltayb
Sindy, Abdulfattah I.
Sadiq, Bakr M. Bin
Althaqafi, Abdulhakeem O.
Shabouni, Omaima
Banjar, Ayman
Haynes, Lia M.
Gerber, Susan I.
Feikin, Daniel R.
Madani, Tariq A.
Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014
title Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014
title_full Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014
title_fullStr Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014
title_full_unstemmed Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014
title_short Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014
title_sort middle east respiratory syndrome coronavirus transmission in extended family, saudi arabia, 2014
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982159/
https://www.ncbi.nlm.nih.gov/pubmed/27191038
http://dx.doi.org/10.3201/eid2208.152015
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