Major Persistent 5′ Terminally Deleted Coxsackievirus B3 Populations in Human Endomyocardial Tissues

We performed deep sequencing analysis of the enterovirus 5′ noncoding region in cardiac biopsies from a patient with dilated cardiomyopathy. Results displayed a mix of deleted and full-length coxsackievirus B3, characterized by a low viral RNA load (8.10(2) copies/μg of nucleic acids) and a low vira...

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Autores principales: Bouin, Alexis, Nguyen, Yohan, Wehbe, Michel, Renois, Fanny, Fornes, Paul, Bani-Sadr, Firouze, Metz, Damien, Andreoletti, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2016
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982168/
https://www.ncbi.nlm.nih.gov/pubmed/27434549
http://dx.doi.org/10.3201/eid2208.160186
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author Bouin, Alexis
Nguyen, Yohan
Wehbe, Michel
Renois, Fanny
Fornes, Paul
Bani-Sadr, Firouze
Metz, Damien
Andreoletti, Laurent
author_facet Bouin, Alexis
Nguyen, Yohan
Wehbe, Michel
Renois, Fanny
Fornes, Paul
Bani-Sadr, Firouze
Metz, Damien
Andreoletti, Laurent
author_sort Bouin, Alexis
collection PubMed
description We performed deep sequencing analysis of the enterovirus 5′ noncoding region in cardiac biopsies from a patient with dilated cardiomyopathy. Results displayed a mix of deleted and full-length coxsackievirus B3, characterized by a low viral RNA load (8.10(2) copies/μg of nucleic acids) and a low viral RNA positive-sense to RNA negative-sense ratio of 4.8.
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spelling pubmed-49821682016-08-12 Major Persistent 5′ Terminally Deleted Coxsackievirus B3 Populations in Human Endomyocardial Tissues Bouin, Alexis Nguyen, Yohan Wehbe, Michel Renois, Fanny Fornes, Paul Bani-Sadr, Firouze Metz, Damien Andreoletti, Laurent Emerg Infect Dis Dispatch We performed deep sequencing analysis of the enterovirus 5′ noncoding region in cardiac biopsies from a patient with dilated cardiomyopathy. Results displayed a mix of deleted and full-length coxsackievirus B3, characterized by a low viral RNA load (8.10(2) copies/μg of nucleic acids) and a low viral RNA positive-sense to RNA negative-sense ratio of 4.8. Centers for Disease Control and Prevention 2016-08 /pmc/articles/PMC4982168/ /pubmed/27434549 http://dx.doi.org/10.3201/eid2208.160186 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Bouin, Alexis
Nguyen, Yohan
Wehbe, Michel
Renois, Fanny
Fornes, Paul
Bani-Sadr, Firouze
Metz, Damien
Andreoletti, Laurent
Major Persistent 5′ Terminally Deleted Coxsackievirus B3 Populations in Human Endomyocardial Tissues
title Major Persistent 5′ Terminally Deleted Coxsackievirus B3 Populations in Human Endomyocardial Tissues
title_full Major Persistent 5′ Terminally Deleted Coxsackievirus B3 Populations in Human Endomyocardial Tissues
title_fullStr Major Persistent 5′ Terminally Deleted Coxsackievirus B3 Populations in Human Endomyocardial Tissues
title_full_unstemmed Major Persistent 5′ Terminally Deleted Coxsackievirus B3 Populations in Human Endomyocardial Tissues
title_short Major Persistent 5′ Terminally Deleted Coxsackievirus B3 Populations in Human Endomyocardial Tissues
title_sort major persistent 5′ terminally deleted coxsackievirus b3 populations in human endomyocardial tissues
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982168/
https://www.ncbi.nlm.nih.gov/pubmed/27434549
http://dx.doi.org/10.3201/eid2208.160186
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