Mutated NPM1 in combination with overexpression of Meis1 or Hoxa9 is not sufficient to induce acute myeloid leukemia

BACKGROUND: Acute myeloid leukemia (AML) carrying nucleophosmin 1 (NPM1) mutations (NPMc(+)) is regarded as a separate entity of myeloid neoplasms due to its distinct biological and clinical features. However, NPMc(+) alone displays low leukemogenic activity and cooperating events appear crucial for...

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Detalles Bibliográficos
Autores principales: Wiktorin, Hanna Grauers, Nilsson, Tina, Jansson, Ann, Palmqvist, Lars, Martner, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982317/
https://www.ncbi.nlm.nih.gov/pubmed/27525194
http://dx.doi.org/10.1186/s40164-016-0053-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982317/
https://www.ncbi.nlm.nih.gov/pubmed/27525194
http://dx.doi.org/10.1186/s40164-016-0053-2

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