Cargando…

Mutated NPM1 in combination with overexpression of Meis1 or Hoxa9 is not sufficient to induce acute myeloid leukemia

BACKGROUND: Acute myeloid leukemia (AML) carrying nucleophosmin 1 (NPM1) mutations (NPMc(+)) is regarded as a separate entity of myeloid neoplasms due to its distinct biological and clinical features. However, NPMc(+) alone displays low leukemogenic activity and cooperating events appear crucial for...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wiktorin, Hanna Grauers, Nilsson, Tina, Jansson, Ann, Palmqvist, Lars, Martner, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Rapid Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982317/ https://www.ncbi.nlm.nih.gov/pubmed/27525194 http://dx.doi.org/10.1186/s40164-016-0053-2

Ejemplares similares

Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice
por: Muranyi, Andrew, et al.
Publicado: (2022)

Histamine targets myeloid-derived suppressor cells and improves the anti-tumor efficacy of PD-1/PD-L1 checkpoint blockade
por: Grauers Wiktorin, Hanna, et al.
Publicado: (2018)

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia
por: Mohr, Sebastian, et al.
Publicado: (2017)

NOX2-Derived Reactive Oxygen Species in Cancer
por: Grauers Wiktorin, Hanna, et al.
Publicado: (2020)

HOXA9/MEIS1 targets in leukemia: reinforced signaling networks and therapeutic opportunities
por: Zhou, Xinyue, et al.
Publicado: (2022)

Induction and subsequent decline of S1-specific T cell reactivity after COVID-19 vaccination
por: Törnell, Andreas, et al.
Publicado: (2023)

Impact of IL-1β and the IL-1R antagonist on relapse risk and survival in AML patients undergoing immunotherapy for remission maintenance
por: Grauers Wiktorin, Hanna, et al.
Publicado: (2021)

Anti-Leukemic Properties of Histamine in Monocytic Leukemia: The Role of NOX2
por: Kiffin, Roberta, et al.
Publicado: (2018)

NOX2 inhibition reduces oxidative stress and prolongs survival in murine KRAS-induced myeloproliferative disease
por: Aydin, Ebru, et al.
Publicado: (2018)

Overexpression of HOXA10 is associated with unfavorable prognosis of acute myeloid leukemia
por: Guo, Chao, et al.
Publicado: (2020)

An adjuvant-containing cDC1-targeted recombinant fusion vaccine conveys strong protection against murine melanoma growth and metastasis
por: Arabpour, Mohammad, et al.
Publicado: (2022)

MiR-424 and miR-155 deregulated expression in cytogenetically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status
por: Faraoni, Isabella, et al.
Publicado: (2012)

Acute Promyelocytic Leukemia or Acute Myeloid Leukemia with Mutated NPM1?
por: Cloobs-Venezia, Maximiliano, et al.
Publicado: (2022)

PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia
por: Ropa, James, et al.
Publicado: (2018)

MOZ is critical for the development of MOZ/MLL fusion–induced leukemia through regulation of Hoxa9/Meis1 expression
por: Katsumoto, Takuo, et al.
Publicado: (2022)

Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation
por: Cocciardi, Sibylle, et al.
Publicado: (2019)

Hoxa9/meis1-transgenic zebrafish develops acute myeloid leukaemia-like disease with rapid onset and high penetrance
por: Wang, Wei, et al.
Publicado: (2022)

The Deficiency of Tumor Suppressor Prep1 Accelerates the Onset of Meis1- Hoxa9 Leukemogenesis
por: Dardaei, Leila, et al.
Publicado: (2014)

The frequency of NPM1 mutations in childhood acute myeloid leukemia
por: Braoudaki, Maria, et al.
Publicado: (2010)

Nucleophosmin1 (NPM1) abnormality in hematologic malignancies, and therapeutic targeting of mutant NPM1 in acute myeloid leukemia
por: Chen, Yingyu, et al.
Publicado: (2020)

Acute myeloid leukemia with concurrent NPM1 and RUNX1 mutations
por: Zuo, Zhuang, et al.
Publicado: (2023)

Transient and durable T cell reactivity after COVID-19
por: Martner, Anna, et al.
Publicado: (2022)

Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia
por: Hirsch, Susanne, et al.
Publicado: (2017)

Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations
por: Mariotti, Benedetta, et al.
Publicado: (2019)

Identification of a novel NPM1 mutation in acute myeloid leukemia
por: Yao, Yiyi, et al.
Publicado: (2023)

Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia
por: Schneider, Edith, et al.
Publicado: (2018)

Characterization and dynamics of specific T cells against nucleophosmin-1 (NPM1)-mutated peptides in patients with NPM1-mutated acute myeloid leukemia
por: Forghieri, Fabio, et al.
Publicado: (2019)

Isolated Mediastinal Myeloid Sarcoma after NPM1-Positive Pediatric Acute Myeloid Leukemia
por: Tüfekçi, Özlem, et al.
Publicado: (2019)

Identification of Two Novel NPM1 Mutations in Patients with Acute Myeloid Leukemia
por: Jeon, Yongbum, et al.
Publicado: (2013)

Evaluation of Minimal Residual Disease in Acute Myeloid Leukemia with NPM1 Marker
por: Alizad Ghandforoush, Nasrin, et al.
Publicado: (2016)

Recurrent SETD2 mutation in NPM1-mutated acute myeloid leukemia
por: Sun, Jiewen, et al.
Publicado: (2020)

Genetic, Phenotypic, and Clinical Heterogeneity of NPM1-Mutant Acute Myeloid Leukemias
por: Testa, Ugo, et al.
Publicado: (2023)

Rapid Cytokine Release Assays for Analysis of Severe Acute Respiratory Syndrome Coronavirus 2–Specific T Cells in Whole Blood
por: Törnell, Andreas, et al.
Publicado: (2022)

Distinct regulation of c-myb gene expression by HoxA9, Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells
por: Dassé, E, et al.
Publicado: (2012)

Contribution of CTCF binding to transcriptional activity at the HOXA locus in NPM1-mutant AML cells
por: Ghasemi, Reza, et al.
Publicado: (2020)

Upregulation of SOCS-1 by Nutlin-3 in acute myeloid leukemia cells but not in primary normal cells
por: Tisato, Veronica, et al.
Publicado: (2014)

Molecular study of Nucleophosmin 1(NPM1) gene in acute myeloid leukemia in Kurdish population
por: Othman, Galawezh Obaid, et al.
Publicado: (2021)

NPM1 and FLT3-ITD/TKD Gene Mutations in Acute Myeloid Leukemia
por: Naseem, Shano, et al.
Publicado: (2021)

NPM1A in Plasma is a Potential Prognostic Biomarker in Acute Myeloid Leukemia
por: Sun, Chengming, et al.
Publicado: (2018)

Overexpression of the long non-coding RNA PVT1 is correlated with leukemic cell proliferation in acute promyelocytic leukemia
por: Zeng, Chengwu, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_sssep8ih4cc8ebfa7ec4tfqus1