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Association between mesothelin expression and survival outcomes in patients with triple-negative breast cancer: a protocol for a systematic review
BACKGROUND: Mesothelin is a membrane-bound glycoprotein. Although the biologic function of mesothelin is not very clear, researchers have found that it plays a role in the survival, proliferation, and migration of tumor cells. Identified as a tumor-associated biomarker, mesothelin is more often over...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982336/ https://www.ncbi.nlm.nih.gov/pubmed/27514374 http://dx.doi.org/10.1186/s13643-016-0313-6 |
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author | Wang, Mei Li, Aihua Sun, Guangwen Mbuagbaw, Lawrence Reid, Susan Lovrics, Peter J. Thabane, Lehana |
author_facet | Wang, Mei Li, Aihua Sun, Guangwen Mbuagbaw, Lawrence Reid, Susan Lovrics, Peter J. Thabane, Lehana |
author_sort | Wang, Mei |
collection | PubMed |
description | BACKGROUND: Mesothelin is a membrane-bound glycoprotein. Although the biologic function of mesothelin is not very clear, researchers have found that it plays a role in the survival, proliferation, and migration of tumor cells. Identified as a tumor-associated biomarker, mesothelin is more often overexpressed in triple-negative breast cancer (TNBC) than in common luminal breast tumor subtype or normal tissues. The objective of this review is to determine the association between the expression of mesothelin and overall survival in patients with TNBC. METHODS/DESIGN: We will search the following electronic databases: MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, and Web of Science with no time or language restriction. Prospective or retrospective longitudinal studies that investigate mesothelin expression in TNBC or the prognosis of TNBC with mesothelin baseline measurement will be selected. Two reviewers will independently assess every abstract or full text for inclusion. Data on clinical outcomes, as well as on study design, research setting, study population, demographic characteristics of the participants, and methodological quality, will be extracted using a structured codebook developed by the authors. A pooled measure of associations will be assessed through meta-analyses if appropriate. Heterogeneity across the included studies will be evaluated using the I(2) statistics. Findings will be reported according to the Meta-Analysis of Observational Studies in Epidemiology (MOOSE) guidelines and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The quality of evidence and risk of bias of the studies will be evaluated. DISCUSSION: The aim of this systematic review is to synthesize the evidence regarding the association between the expression of mesothelin and the survival outcomes of patients with TNBC. A better understanding of the expression frequency and prognostic value of mesothelin in TNBC will be essential to identifying a novel therapeutic target. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42016036212 ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13643-016-0313-6) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4982336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-49823362016-08-13 Association between mesothelin expression and survival outcomes in patients with triple-negative breast cancer: a protocol for a systematic review Wang, Mei Li, Aihua Sun, Guangwen Mbuagbaw, Lawrence Reid, Susan Lovrics, Peter J. Thabane, Lehana Syst Rev Protocol BACKGROUND: Mesothelin is a membrane-bound glycoprotein. Although the biologic function of mesothelin is not very clear, researchers have found that it plays a role in the survival, proliferation, and migration of tumor cells. Identified as a tumor-associated biomarker, mesothelin is more often overexpressed in triple-negative breast cancer (TNBC) than in common luminal breast tumor subtype or normal tissues. The objective of this review is to determine the association between the expression of mesothelin and overall survival in patients with TNBC. METHODS/DESIGN: We will search the following electronic databases: MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, and Web of Science with no time or language restriction. Prospective or retrospective longitudinal studies that investigate mesothelin expression in TNBC or the prognosis of TNBC with mesothelin baseline measurement will be selected. Two reviewers will independently assess every abstract or full text for inclusion. Data on clinical outcomes, as well as on study design, research setting, study population, demographic characteristics of the participants, and methodological quality, will be extracted using a structured codebook developed by the authors. A pooled measure of associations will be assessed through meta-analyses if appropriate. Heterogeneity across the included studies will be evaluated using the I(2) statistics. Findings will be reported according to the Meta-Analysis of Observational Studies in Epidemiology (MOOSE) guidelines and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The quality of evidence and risk of bias of the studies will be evaluated. DISCUSSION: The aim of this systematic review is to synthesize the evidence regarding the association between the expression of mesothelin and the survival outcomes of patients with TNBC. A better understanding of the expression frequency and prognostic value of mesothelin in TNBC will be essential to identifying a novel therapeutic target. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42016036212 ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13643-016-0313-6) contains supplementary material, which is available to authorized users. BioMed Central 2016-08-11 /pmc/articles/PMC4982336/ /pubmed/27514374 http://dx.doi.org/10.1186/s13643-016-0313-6 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Protocol Wang, Mei Li, Aihua Sun, Guangwen Mbuagbaw, Lawrence Reid, Susan Lovrics, Peter J. Thabane, Lehana Association between mesothelin expression and survival outcomes in patients with triple-negative breast cancer: a protocol for a systematic review |
title | Association between mesothelin expression and survival outcomes in patients with triple-negative breast cancer: a protocol for a systematic review |
title_full | Association between mesothelin expression and survival outcomes in patients with triple-negative breast cancer: a protocol for a systematic review |
title_fullStr | Association between mesothelin expression and survival outcomes in patients with triple-negative breast cancer: a protocol for a systematic review |
title_full_unstemmed | Association between mesothelin expression and survival outcomes in patients with triple-negative breast cancer: a protocol for a systematic review |
title_short | Association between mesothelin expression and survival outcomes in patients with triple-negative breast cancer: a protocol for a systematic review |
title_sort | association between mesothelin expression and survival outcomes in patients with triple-negative breast cancer: a protocol for a systematic review |
topic | Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982336/ https://www.ncbi.nlm.nih.gov/pubmed/27514374 http://dx.doi.org/10.1186/s13643-016-0313-6 |
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