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Cost of rotavirus diarrhea for programmatic evaluation of vaccination in Vietnam

BACKGROUND: Rotavirus is the most common etiology of diarrhea-associated hospitalizations and clinic visits in Vietnamese children < 5 years old. To estimate the economic burden of rotavirus-associated formal healthcare encounters, an economic study was conducted. METHODS: A cost-of-illness study...

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Autores principales: Riewpaiboon, Arthorn, Shin, Sunheang, Le, Thi Phuong Mai, Vu, Dinh Thiem, Nguyen, Thi Hien Anh, Alexander, Neal, Dang, Duc Anh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982427/
https://www.ncbi.nlm.nih.gov/pubmed/27514373
http://dx.doi.org/10.1186/s12889-016-3458-2
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author Riewpaiboon, Arthorn
Shin, Sunheang
Le, Thi Phuong Mai
Vu, Dinh Thiem
Nguyen, Thi Hien Anh
Alexander, Neal
Dang, Duc Anh
author_facet Riewpaiboon, Arthorn
Shin, Sunheang
Le, Thi Phuong Mai
Vu, Dinh Thiem
Nguyen, Thi Hien Anh
Alexander, Neal
Dang, Duc Anh
author_sort Riewpaiboon, Arthorn
collection PubMed
description BACKGROUND: Rotavirus is the most common etiology of diarrhea-associated hospitalizations and clinic visits in Vietnamese children < 5 years old. To estimate the economic burden of rotavirus-associated formal healthcare encounters, an economic study was conducted. METHODS: A cost-of-illness study was performed from a societal perspective. Data were collected from children below the age of five years who presented to a clinic or hospital with symptoms of acute gastroenteritis (AGE). Patient-specific information on resource use and cost was obtained through caregiver interviews and medical chart review. Costs are presented in 2014 US dollar ($). RESULTS: A total of 557 children with symptoms of AGE were enrolled from March through June 2009, with mean age of 16.5 months. Of the 340 outpatients and 217 admitted patients enrolled, 41 % tested rotavirus positive. It was found that, from a societal perspective, the mean total cost of AGE was $175. Costs of patients with and without rotavirus were $217 and $158, respectively. From multiple regression analysis, it was found that rotavirus infection, patient age and receiving oral rehydration solution before visiting health facility had significant effect on the costs. CONCLUSIONS: This study clearly demonstrated substantial economic burden of AGE including rotavirus disease. They were significantly greater than the previously reported cost estimates in Vietnam. These updated costs of illness result in more favorable vaccine cost-effectiveness than in previous economic evaluations.
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spelling pubmed-49824272016-08-13 Cost of rotavirus diarrhea for programmatic evaluation of vaccination in Vietnam Riewpaiboon, Arthorn Shin, Sunheang Le, Thi Phuong Mai Vu, Dinh Thiem Nguyen, Thi Hien Anh Alexander, Neal Dang, Duc Anh BMC Public Health Research Article BACKGROUND: Rotavirus is the most common etiology of diarrhea-associated hospitalizations and clinic visits in Vietnamese children < 5 years old. To estimate the economic burden of rotavirus-associated formal healthcare encounters, an economic study was conducted. METHODS: A cost-of-illness study was performed from a societal perspective. Data were collected from children below the age of five years who presented to a clinic or hospital with symptoms of acute gastroenteritis (AGE). Patient-specific information on resource use and cost was obtained through caregiver interviews and medical chart review. Costs are presented in 2014 US dollar ($). RESULTS: A total of 557 children with symptoms of AGE were enrolled from March through June 2009, with mean age of 16.5 months. Of the 340 outpatients and 217 admitted patients enrolled, 41 % tested rotavirus positive. It was found that, from a societal perspective, the mean total cost of AGE was $175. Costs of patients with and without rotavirus were $217 and $158, respectively. From multiple regression analysis, it was found that rotavirus infection, patient age and receiving oral rehydration solution before visiting health facility had significant effect on the costs. CONCLUSIONS: This study clearly demonstrated substantial economic burden of AGE including rotavirus disease. They were significantly greater than the previously reported cost estimates in Vietnam. These updated costs of illness result in more favorable vaccine cost-effectiveness than in previous economic evaluations. BioMed Central 2016-08-11 /pmc/articles/PMC4982427/ /pubmed/27514373 http://dx.doi.org/10.1186/s12889-016-3458-2 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Riewpaiboon, Arthorn
Shin, Sunheang
Le, Thi Phuong Mai
Vu, Dinh Thiem
Nguyen, Thi Hien Anh
Alexander, Neal
Dang, Duc Anh
Cost of rotavirus diarrhea for programmatic evaluation of vaccination in Vietnam
title Cost of rotavirus diarrhea for programmatic evaluation of vaccination in Vietnam
title_full Cost of rotavirus diarrhea for programmatic evaluation of vaccination in Vietnam
title_fullStr Cost of rotavirus diarrhea for programmatic evaluation of vaccination in Vietnam
title_full_unstemmed Cost of rotavirus diarrhea for programmatic evaluation of vaccination in Vietnam
title_short Cost of rotavirus diarrhea for programmatic evaluation of vaccination in Vietnam
title_sort cost of rotavirus diarrhea for programmatic evaluation of vaccination in vietnam
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982427/
https://www.ncbi.nlm.nih.gov/pubmed/27514373
http://dx.doi.org/10.1186/s12889-016-3458-2
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