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Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease
INTRODUCTION: The genetics underlying posterior cortical atrophy (PCA), typically a rare variant of Alzheimer's disease (AD), remain uncertain. METHODS: We genotyped 302 PCA patients from 11 centers, calculated risk at 24 loci for AD/DLB and performed an exploratory genome-wide association stud...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier, Inc
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982482/ https://www.ncbi.nlm.nih.gov/pubmed/26993346 http://dx.doi.org/10.1016/j.jalz.2016.01.010 |
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author | Schott, Jonathan M. Crutch, Sebastian J. Carrasquillo, Minerva M. Uphill, James Shakespeare, Tim J. Ryan, Natalie S. Yong, Keir X. Lehmann, Manja Ertekin-Taner, Nilufer Graff-Radford, Neill R. Boeve, Bradley F. Murray, Melissa E. Khan, Qurat ul Ain Petersen, Ronald C. Dickson, Dennis W. Knopman, David S. Rabinovici, Gil D. Miller, Bruce L. González, Aida Suárez Gil-Néciga, Eulogio Snowden, Julie S. Harris, Jenny Pickering-Brown, Stuart M. Louwersheimer, Eva van der Flier, Wiesje M. Scheltens, Philip Pijnenburg, Yolande A. Galasko, Douglas Sarazin, Marie Dubois, Bruno Magnin, Eloi Galimberti, Daniela Scarpini, Elio Cappa, Stefano F. Hodges, John R. Halliday, Glenda M. Bartley, Lauren Carrillo, Maria C. Bras, Jose T. Hardy, John Rossor, Martin N. Collinge, John Fox, Nick C. Mead, Simon |
author_facet | Schott, Jonathan M. Crutch, Sebastian J. Carrasquillo, Minerva M. Uphill, James Shakespeare, Tim J. Ryan, Natalie S. Yong, Keir X. Lehmann, Manja Ertekin-Taner, Nilufer Graff-Radford, Neill R. Boeve, Bradley F. Murray, Melissa E. Khan, Qurat ul Ain Petersen, Ronald C. Dickson, Dennis W. Knopman, David S. Rabinovici, Gil D. Miller, Bruce L. González, Aida Suárez Gil-Néciga, Eulogio Snowden, Julie S. Harris, Jenny Pickering-Brown, Stuart M. Louwersheimer, Eva van der Flier, Wiesje M. Scheltens, Philip Pijnenburg, Yolande A. Galasko, Douglas Sarazin, Marie Dubois, Bruno Magnin, Eloi Galimberti, Daniela Scarpini, Elio Cappa, Stefano F. Hodges, John R. Halliday, Glenda M. Bartley, Lauren Carrillo, Maria C. Bras, Jose T. Hardy, John Rossor, Martin N. Collinge, John Fox, Nick C. Mead, Simon |
author_sort | Schott, Jonathan M. |
collection | PubMed |
description | INTRODUCTION: The genetics underlying posterior cortical atrophy (PCA), typically a rare variant of Alzheimer's disease (AD), remain uncertain. METHODS: We genotyped 302 PCA patients from 11 centers, calculated risk at 24 loci for AD/DLB and performed an exploratory genome-wide association study. RESULTS: We confirm that variation in/near APOE/TOMM40 (P = 6 × 10(−14)) alters PCA risk, but with smaller effect than for typical AD (PCA: odds ratio [OR] = 2.03, typical AD: OR = 2.83, P = .0007). We found evidence for risk in/near CR1 (P = 7 × 10(−4)), ABCA7 (P = .02) and BIN1 (P = .04). ORs at variants near INPP5D and NME8 did not overlap between PCA and typical AD. Exploratory genome-wide association studies confirmed APOE and identified three novel loci: rs76854344 near CNTNAP5 (P = 8 × 10(−10) OR = 1.9 [1.5–2.3]); rs72907046 near FAM46A (P = 1 × 10(−9) OR = 3.2 [2.1–4.9]); and rs2525776 near SEMA3C (P = 1 × 10(−8), OR = 3.3 [2.1–5.1]). DISCUSSION: We provide evidence for genetic risk factors specifically related to PCA. We identify three candidate loci that, if replicated, may provide insights into selective vulnerability and phenotypic diversity in AD. |
format | Online Article Text |
id | pubmed-4982482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier, Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-49824822016-08-19 Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease Schott, Jonathan M. Crutch, Sebastian J. Carrasquillo, Minerva M. Uphill, James Shakespeare, Tim J. Ryan, Natalie S. Yong, Keir X. Lehmann, Manja Ertekin-Taner, Nilufer Graff-Radford, Neill R. Boeve, Bradley F. Murray, Melissa E. Khan, Qurat ul Ain Petersen, Ronald C. Dickson, Dennis W. Knopman, David S. Rabinovici, Gil D. Miller, Bruce L. González, Aida Suárez Gil-Néciga, Eulogio Snowden, Julie S. Harris, Jenny Pickering-Brown, Stuart M. Louwersheimer, Eva van der Flier, Wiesje M. Scheltens, Philip Pijnenburg, Yolande A. Galasko, Douglas Sarazin, Marie Dubois, Bruno Magnin, Eloi Galimberti, Daniela Scarpini, Elio Cappa, Stefano F. Hodges, John R. Halliday, Glenda M. Bartley, Lauren Carrillo, Maria C. Bras, Jose T. Hardy, John Rossor, Martin N. Collinge, John Fox, Nick C. Mead, Simon Alzheimers Dement Featured Article INTRODUCTION: The genetics underlying posterior cortical atrophy (PCA), typically a rare variant of Alzheimer's disease (AD), remain uncertain. METHODS: We genotyped 302 PCA patients from 11 centers, calculated risk at 24 loci for AD/DLB and performed an exploratory genome-wide association study. RESULTS: We confirm that variation in/near APOE/TOMM40 (P = 6 × 10(−14)) alters PCA risk, but with smaller effect than for typical AD (PCA: odds ratio [OR] = 2.03, typical AD: OR = 2.83, P = .0007). We found evidence for risk in/near CR1 (P = 7 × 10(−4)), ABCA7 (P = .02) and BIN1 (P = .04). ORs at variants near INPP5D and NME8 did not overlap between PCA and typical AD. Exploratory genome-wide association studies confirmed APOE and identified three novel loci: rs76854344 near CNTNAP5 (P = 8 × 10(−10) OR = 1.9 [1.5–2.3]); rs72907046 near FAM46A (P = 1 × 10(−9) OR = 3.2 [2.1–4.9]); and rs2525776 near SEMA3C (P = 1 × 10(−8), OR = 3.3 [2.1–5.1]). DISCUSSION: We provide evidence for genetic risk factors specifically related to PCA. We identify three candidate loci that, if replicated, may provide insights into selective vulnerability and phenotypic diversity in AD. Elsevier, Inc 2016-08 /pmc/articles/PMC4982482/ /pubmed/26993346 http://dx.doi.org/10.1016/j.jalz.2016.01.010 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Featured Article Schott, Jonathan M. Crutch, Sebastian J. Carrasquillo, Minerva M. Uphill, James Shakespeare, Tim J. Ryan, Natalie S. Yong, Keir X. Lehmann, Manja Ertekin-Taner, Nilufer Graff-Radford, Neill R. Boeve, Bradley F. Murray, Melissa E. Khan, Qurat ul Ain Petersen, Ronald C. Dickson, Dennis W. Knopman, David S. Rabinovici, Gil D. Miller, Bruce L. González, Aida Suárez Gil-Néciga, Eulogio Snowden, Julie S. Harris, Jenny Pickering-Brown, Stuart M. Louwersheimer, Eva van der Flier, Wiesje M. Scheltens, Philip Pijnenburg, Yolande A. Galasko, Douglas Sarazin, Marie Dubois, Bruno Magnin, Eloi Galimberti, Daniela Scarpini, Elio Cappa, Stefano F. Hodges, John R. Halliday, Glenda M. Bartley, Lauren Carrillo, Maria C. Bras, Jose T. Hardy, John Rossor, Martin N. Collinge, John Fox, Nick C. Mead, Simon Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease |
title | Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease |
title_full | Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease |
title_fullStr | Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease |
title_full_unstemmed | Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease |
title_short | Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease |
title_sort | genetic risk factors for the posterior cortical atrophy variant of alzheimer's disease |
topic | Featured Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982482/ https://www.ncbi.nlm.nih.gov/pubmed/26993346 http://dx.doi.org/10.1016/j.jalz.2016.01.010 |
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