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Using ferromagnetic nanoparticles with low Curie temperature for magnetic resonance imaging-guided thermoablation
INTRODUCTION: Magnetic nanoparticles (NPs) represent a tool for use in magnetic resonance imaging (MRI)-guided thermoablation of tumors using an external high-frequency (HF) magnetic field. To avoid local overheating, perovskite NPs with a lower Curie temperature (T(c)) were proposed for use in ther...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982507/ https://www.ncbi.nlm.nih.gov/pubmed/27540292 http://dx.doi.org/10.2147/IJN.S109582 |
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author | Herynek, Vít Turnovcová, Karolína Veverka, Pavel Dědourková, Tereza Žvátora, Pavel Jendelová, Pavla Gálisová, Andrea Kosinová, Lucie Jiráková, Klára Syková, Eva |
author_facet | Herynek, Vít Turnovcová, Karolína Veverka, Pavel Dědourková, Tereza Žvátora, Pavel Jendelová, Pavla Gálisová, Andrea Kosinová, Lucie Jiráková, Klára Syková, Eva |
author_sort | Herynek, Vít |
collection | PubMed |
description | INTRODUCTION: Magnetic nanoparticles (NPs) represent a tool for use in magnetic resonance imaging (MRI)-guided thermoablation of tumors using an external high-frequency (HF) magnetic field. To avoid local overheating, perovskite NPs with a lower Curie temperature (T(c)) were proposed for use in thermotherapy. However, deposited power decreases when approaching the Curie temperature and consequently may not be sufficient for effective ablation. The goal of the study was to test this hypothesis. METHODS: Perovskite NPs (T(c) =66°C–74°C) were characterized and tested both in vitro and in vivo. In vitro, the cells suspended with NPs were exposed to a HF magnetic field together with control samples. In vivo, a NP suspension was injected into a induced tumor in rats. Distribution was checked by MRI and the rats were exposed to a HF field together with control animals. Apoptosis in the tissue was evaluated. RESULTS AND DISCUSSION: In vitro, the high concentration of suspended NPs caused an increase of the temperature in the cell sample, leading to cell death. In vivo, MRI confirmed distribution of the NPs in the tumor. The temperature in the tumor with injected NPs did not increase substantially in comparison with animals without particles during HF exposure. We proved that the deposited power from the NPs is too small and that thermoregulation of the animal is sufficient to conduct the heat away. Histology did not detect substantially higher apoptosis in NP-treated animals after ablation. CONCLUSION: Magnetic particles with low T(c) can be tracked in vivo by MRI and heated by a HF field. The particles are capable of inducing cell apoptosis in suspensions in vitro at high concentrations only. However, their effect in the case of extracellular deposition in vivo is questionable due to low deposited power and active thermoregulation of the tissue. |
format | Online Article Text |
id | pubmed-4982507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-49825072016-08-18 Using ferromagnetic nanoparticles with low Curie temperature for magnetic resonance imaging-guided thermoablation Herynek, Vít Turnovcová, Karolína Veverka, Pavel Dědourková, Tereza Žvátora, Pavel Jendelová, Pavla Gálisová, Andrea Kosinová, Lucie Jiráková, Klára Syková, Eva Int J Nanomedicine Original Research INTRODUCTION: Magnetic nanoparticles (NPs) represent a tool for use in magnetic resonance imaging (MRI)-guided thermoablation of tumors using an external high-frequency (HF) magnetic field. To avoid local overheating, perovskite NPs with a lower Curie temperature (T(c)) were proposed for use in thermotherapy. However, deposited power decreases when approaching the Curie temperature and consequently may not be sufficient for effective ablation. The goal of the study was to test this hypothesis. METHODS: Perovskite NPs (T(c) =66°C–74°C) were characterized and tested both in vitro and in vivo. In vitro, the cells suspended with NPs were exposed to a HF magnetic field together with control samples. In vivo, a NP suspension was injected into a induced tumor in rats. Distribution was checked by MRI and the rats were exposed to a HF field together with control animals. Apoptosis in the tissue was evaluated. RESULTS AND DISCUSSION: In vitro, the high concentration of suspended NPs caused an increase of the temperature in the cell sample, leading to cell death. In vivo, MRI confirmed distribution of the NPs in the tumor. The temperature in the tumor with injected NPs did not increase substantially in comparison with animals without particles during HF exposure. We proved that the deposited power from the NPs is too small and that thermoregulation of the animal is sufficient to conduct the heat away. Histology did not detect substantially higher apoptosis in NP-treated animals after ablation. CONCLUSION: Magnetic particles with low T(c) can be tracked in vivo by MRI and heated by a HF field. The particles are capable of inducing cell apoptosis in suspensions in vitro at high concentrations only. However, their effect in the case of extracellular deposition in vivo is questionable due to low deposited power and active thermoregulation of the tissue. Dove Medical Press 2016-08-08 /pmc/articles/PMC4982507/ /pubmed/27540292 http://dx.doi.org/10.2147/IJN.S109582 Text en © 2016 Herynek et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Herynek, Vít Turnovcová, Karolína Veverka, Pavel Dědourková, Tereza Žvátora, Pavel Jendelová, Pavla Gálisová, Andrea Kosinová, Lucie Jiráková, Klára Syková, Eva Using ferromagnetic nanoparticles with low Curie temperature for magnetic resonance imaging-guided thermoablation |
title | Using ferromagnetic nanoparticles with low Curie temperature for magnetic resonance imaging-guided thermoablation |
title_full | Using ferromagnetic nanoparticles with low Curie temperature for magnetic resonance imaging-guided thermoablation |
title_fullStr | Using ferromagnetic nanoparticles with low Curie temperature for magnetic resonance imaging-guided thermoablation |
title_full_unstemmed | Using ferromagnetic nanoparticles with low Curie temperature for magnetic resonance imaging-guided thermoablation |
title_short | Using ferromagnetic nanoparticles with low Curie temperature for magnetic resonance imaging-guided thermoablation |
title_sort | using ferromagnetic nanoparticles with low curie temperature for magnetic resonance imaging-guided thermoablation |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982507/ https://www.ncbi.nlm.nih.gov/pubmed/27540292 http://dx.doi.org/10.2147/IJN.S109582 |
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