Cargando…
Deficiency and Also Transgenic Overexpression of Timp-3 Both Lead to Compromised Bone Mass and Architecture In Vivo
Tissue inhibitor of metalloproteinases-3 (TIMP-3) regulates extracellular matrix via its inhibition of matrix metalloproteinases and membrane-bound sheddases. Timp-3 is expressed at multiple sites of extensive tissue remodelling. This extends to bone where its role, however, remains largely unresolv...
Autores principales: | Javaheri, Behzad, Hopkinson, Mark, Poulet, Blandine, Pollard, Andrea S., Shefelbine, Sandra J., Chang, Yu-Mei, Francis-West, Philippa, Bou-Gharios, George, Pitsillides, Andrew A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982603/ https://www.ncbi.nlm.nih.gov/pubmed/27519049 http://dx.doi.org/10.1371/journal.pone.0159657 |
Ejemplares similares
-
Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity
por: Poulet, Blandine, et al.
Publicado: (2016) -
Meniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis
por: Ramos-Mucci, Lorenzo, et al.
Publicado: (2020) -
The Chondro-Osseous Continuum: Is It Possible to Unlock the Potential Assigned Within?
por: Javaheri, Behzad, et al.
Publicado: (2018) -
Stable sulforaphane protects against gait anomalies and modifies bone microarchitecture in the spontaneous STR/Ort model of osteoarthritis
por: Javaheri, Behzad, et al.
Publicado: (2017) -
Age and Sex Differences in Load‐Induced Tibial Cortical Bone Surface Strain Maps
por: Carriero, Alessandra, et al.
Publicado: (2021)