7SK-BAF axis controls pervasive transcription at enhancers

RNA functions at enhancers remain mysterious. Here we show that the 7SK small nuclear RNA (snRNA) inhibits enhancer transcription by modulating nucleosome position. 7SK occupies enhancers and super enhancers genome-wide in mouse and human cells, and 7SK is required to limit eRNA initiation and synth...

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Detalles Bibliográficos
Autores principales: Flynn, Ryan A., Do, Brian T., Rubin, Adam J., Calo, Eliezer, Lee, Byron, Kuchelmeister, Hannes, Rale, Michael, Chu, Ci, Kool, Eric T., Wysocka, Joanna, Khavari, Paul A., Chang, Howard Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982704/
https://www.ncbi.nlm.nih.gov/pubmed/26878240
http://dx.doi.org/10.1038/nsmb.3176

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