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PNA clamping-assisted fluorescence melting curve analysis for detecting EGFR and KRAS mutations in the circulating tumor DNA of patients with advanced non-small cell lung cancer

BACKGROUND: Circulating cell-free DNA (cfDNA) is emerging as a surrogate sample type for mutation analyses. To improve the clinical utility of cfDNA, we developed a sensitive peptide nucleic acid (PNA)-based method for analyzing EGFR and KRAS mutations in the plasma cfDNA of patients with advanced n...

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Detalles Bibliográficos
Autores principales:	Han, Ji-Youn, Choi, Jae-Jin, Kim, Jin Young, Han, You Lim, Lee, Geon Kook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983013/ https://www.ncbi.nlm.nih.gov/pubmed/27519791 http://dx.doi.org/10.1186/s12885-016-2678-2

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