Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract

BACKGROUND: Gigantol and syringic acid (SA) have been shown to synergistically prevent formation of diabetic cataract (DC). However, the exact mechanism of this effect is unknown. Here, we investigate the effect of these compounds on the activity of aldose reductase (AR) and cataract formation. METH...

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Detalles Bibliográficos
Autores principales: Wu, Jie, Li, Xue, Fang, Hua, Yi, Yanqun, Chen, Dan, Long, Yan, Gao, Xinxin, Wei, Xiaoyong, Chen, C-Y. Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983052/
https://www.ncbi.nlm.nih.gov/pubmed/27520089
http://dx.doi.org/10.1186/s12906-016-1251-5

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