The Luteinizing Hormone-Testosterone Pathway Regulates Mouse Spermatogonial Stem Cell Self-Renewal by Suppressing WNT5A Expression in Sertoli Cells

Spermatogenesis originates from self-renewal of spermatogonial stem cells (SSCs). Previous studies have reported conflicting roles of gonadotropic pituitary hormones in SSC self-renewal. Here, we explored the role of hormonal regulation of SSCs using Fshb and Lhcgr knockout (KO) mice. Although folli...

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Detalles Bibliográficos
Autores principales: Tanaka, Takashi, Kanatsu-Shinohara, Mito, Lei, Zhenmin, Rao, C.V., Shinohara, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983063/
https://www.ncbi.nlm.nih.gov/pubmed/27509137
http://dx.doi.org/10.1016/j.stemcr.2016.07.005

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