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Integrin-Associated Focal Adhesion Kinase Protects Human Embryonic Stem Cells from Apoptosis, Detachment, and Differentiation

Human embryonic stem cells (hESCs) can be maintained in a fully defined niche on extracellular matrix substrates, to which they attach through integrin receptors. However, the underlying integrin signaling mechanisms, and their contribution to hESC behavior, are largely unknown. Here, we show that f...

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Detalles Bibliográficos
Autores principales: Vitillo, Loriana, Baxter, Melissa, Iskender, Banu, Whiting, Paul, Kimber, Susan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983079/
https://www.ncbi.nlm.nih.gov/pubmed/27509133
http://dx.doi.org/10.1016/j.stemcr.2016.07.006