Cargando…

High levels of serum vitamin D are associated with a decreased risk of metabolic diseases in both men and women, but an increased risk for coronary artery calcification in Korean men

BACKGROUND: There are conflicting results for relationships between serum vitamin D levels and metabolic diseases. The aim of this study was to investigate whether serum vitamin D levels were associated with various metabolic diseases including insulin resistance (IR), metabolic syndrome (MS), fatty...

Descripción completa

Detalles Bibliográficos
Autores principales: Sung, Ki-Chul, Chang, Yoosoo, Ryu, Seungho, Chung, Hye-Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983097/
https://www.ncbi.nlm.nih.gov/pubmed/27519883
http://dx.doi.org/10.1186/s12933-016-0432-3
_version_ 1782447861159428096
author Sung, Ki-Chul
Chang, Yoosoo
Ryu, Seungho
Chung, Hye-Kyung
author_facet Sung, Ki-Chul
Chang, Yoosoo
Ryu, Seungho
Chung, Hye-Kyung
author_sort Sung, Ki-Chul
collection PubMed
description BACKGROUND: There are conflicting results for relationships between serum vitamin D levels and metabolic diseases. The aim of this study was to investigate whether serum vitamin D levels were associated with various metabolic diseases including insulin resistance (IR), metabolic syndrome (MS), fatty liver (FL), and coronary artery calcification (CAC), along with assessing gender differences for these relationships in Korean adults. METHODS: A total of 180,918 subjects (98,412 men and 82,506 women) who participated in a comprehensive health examination in the 2012–2013 period at Kangbuk Samsung Hospital, College of Medicine, Sungkyunkwan University were included. Serum vitamin D and metabolic markers were analyzed and CAC was estimated. Subjects were divided according to quartile groups of serum vitamin D. To examine the relationships of serum vitamin D to metabolic diseases and metabolic factors, multivariate logistic analysis was conducted. RESULTS: High levels of serum vitamin D was associated with lower ORs for MS, IR and FL both in men and women (all p < 0.05). For men, ORs for CAC were significantly higher in third and the highest quartile groups for serum vitamin D in all the analyzed models (all p < 0.05). However, women showed no significant results between serum vitamin D and CAC. CONCLUSIONS: High levels of serum vitamin D were associated with lower risk of MS, IR and FL in both Korean men and women, but were associated with higher risk of CAC only in men, and not in women. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12933-016-0432-3) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-4983097
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-49830972016-08-14 High levels of serum vitamin D are associated with a decreased risk of metabolic diseases in both men and women, but an increased risk for coronary artery calcification in Korean men Sung, Ki-Chul Chang, Yoosoo Ryu, Seungho Chung, Hye-Kyung Cardiovasc Diabetol Original Investigation BACKGROUND: There are conflicting results for relationships between serum vitamin D levels and metabolic diseases. The aim of this study was to investigate whether serum vitamin D levels were associated with various metabolic diseases including insulin resistance (IR), metabolic syndrome (MS), fatty liver (FL), and coronary artery calcification (CAC), along with assessing gender differences for these relationships in Korean adults. METHODS: A total of 180,918 subjects (98,412 men and 82,506 women) who participated in a comprehensive health examination in the 2012–2013 period at Kangbuk Samsung Hospital, College of Medicine, Sungkyunkwan University were included. Serum vitamin D and metabolic markers were analyzed and CAC was estimated. Subjects were divided according to quartile groups of serum vitamin D. To examine the relationships of serum vitamin D to metabolic diseases and metabolic factors, multivariate logistic analysis was conducted. RESULTS: High levels of serum vitamin D was associated with lower ORs for MS, IR and FL both in men and women (all p < 0.05). For men, ORs for CAC were significantly higher in third and the highest quartile groups for serum vitamin D in all the analyzed models (all p < 0.05). However, women showed no significant results between serum vitamin D and CAC. CONCLUSIONS: High levels of serum vitamin D were associated with lower risk of MS, IR and FL in both Korean men and women, but were associated with higher risk of CAC only in men, and not in women. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12933-016-0432-3) contains supplementary material, which is available to authorized users. BioMed Central 2016-08-12 /pmc/articles/PMC4983097/ /pubmed/27519883 http://dx.doi.org/10.1186/s12933-016-0432-3 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Investigation
Sung, Ki-Chul
Chang, Yoosoo
Ryu, Seungho
Chung, Hye-Kyung
High levels of serum vitamin D are associated with a decreased risk of metabolic diseases in both men and women, but an increased risk for coronary artery calcification in Korean men
title High levels of serum vitamin D are associated with a decreased risk of metabolic diseases in both men and women, but an increased risk for coronary artery calcification in Korean men
title_full High levels of serum vitamin D are associated with a decreased risk of metabolic diseases in both men and women, but an increased risk for coronary artery calcification in Korean men
title_fullStr High levels of serum vitamin D are associated with a decreased risk of metabolic diseases in both men and women, but an increased risk for coronary artery calcification in Korean men
title_full_unstemmed High levels of serum vitamin D are associated with a decreased risk of metabolic diseases in both men and women, but an increased risk for coronary artery calcification in Korean men
title_short High levels of serum vitamin D are associated with a decreased risk of metabolic diseases in both men and women, but an increased risk for coronary artery calcification in Korean men
title_sort high levels of serum vitamin d are associated with a decreased risk of metabolic diseases in both men and women, but an increased risk for coronary artery calcification in korean men
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983097/
https://www.ncbi.nlm.nih.gov/pubmed/27519883
http://dx.doi.org/10.1186/s12933-016-0432-3
work_keys_str_mv AT sungkichul highlevelsofserumvitamindareassociatedwithadecreasedriskofmetabolicdiseasesinbothmenandwomenbutanincreasedriskforcoronaryarterycalcificationinkoreanmen
AT changyoosoo highlevelsofserumvitamindareassociatedwithadecreasedriskofmetabolicdiseasesinbothmenandwomenbutanincreasedriskforcoronaryarterycalcificationinkoreanmen
AT ryuseungho highlevelsofserumvitamindareassociatedwithadecreasedriskofmetabolicdiseasesinbothmenandwomenbutanincreasedriskforcoronaryarterycalcificationinkoreanmen
AT chunghyekyung highlevelsofserumvitamindareassociatedwithadecreasedriskofmetabolicdiseasesinbothmenandwomenbutanincreasedriskforcoronaryarterycalcificationinkoreanmen