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Omeprazole impairs vascular redox biology and causes xanthine oxidoreductase-mediated endothelial dysfunction

Proton pump inhibitors (PPIs) are widely used drugs that may increase the cardiovascular risk by mechanisms not entirely known. While PPIs increase asymmetric dimethylarginine (ADMA) levels and inhibit nitric oxide production, it is unknown whether impaired vascular redox biology resulting of increa...

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Detalles Bibliográficos
Autores principales: Pinheiro, Lucas C., Oliveira-Paula, Gustavo H., Portella, Rafael L., Guimarães, Danielle A., de Angelis, Celio D., Tanus-Santos, Jose E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983109/
https://www.ncbi.nlm.nih.gov/pubmed/27521759
http://dx.doi.org/10.1016/j.redox.2016.08.001