Cargando…
Effect of endosulfan on immunological competence of layer birds
AIM: The present study was aimed to investigate the immunological competence of endosulfan insecticide after limited oral administration in White Leghorn layer chickens. MATERIALS AND METHODS: A total of 20 White Leghorn birds were given endosulfan in drinking water at 30 ppm/bird/day (no observable...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Veterinary World
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983132/ https://www.ncbi.nlm.nih.gov/pubmed/27536042 http://dx.doi.org/10.14202/vetworld.2016.777-782 |
_version_ | 1782447868924133376 |
---|---|
author | Singh, P. P. Kumar, Ashok Chauhan, R. S. Pankaj, P. K. |
author_facet | Singh, P. P. Kumar, Ashok Chauhan, R. S. Pankaj, P. K. |
author_sort | Singh, P. P. |
collection | PubMed |
description | AIM: The present study was aimed to investigate the immunological competence of endosulfan insecticide after limited oral administration in White Leghorn layer chickens. MATERIALS AND METHODS: A total of 20 White Leghorn birds were given endosulfan in drinking water at 30 ppm/bird/day (no observable effect level dose) for a period of 3-months. Immune competence status of layer birds and chicks hatched from endosulfan offered birds were estimated at 15-day interval in layer birds and at monthly interval in chicks using immunological, biochemical parameters, and teratological estimates. RESULTS: There was a significant decrease in levels of total leukocytes count, absolute lymphocyte count, absolute heterophil count, total serum protein, serum albumin, serum globulin, and serum gamma globulin in the birds fed with endosulfan as compared to control. Similarly, immune competence tests such as lymphocyte stimulation test, oxidative burst assay, and enzyme-linked immunosorbent assay tests indicated lower immunity in birds treated with endosulfan as compared to control. Subsequently, chicks produced from endosulfan-treated birds were also examined for immune competence, but no significant difference was observed between chicks of both the groups. CONCLUSION: The exposure to endosulfan in limited oral dosage was able to exhibit hemo-biochemical and other changes that could be correlated with changes in the immunological profile of layer chickens suggesting cautious usage of endosulfan insecticide in poultry sheds. |
format | Online Article Text |
id | pubmed-4983132 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Veterinary World |
record_format | MEDLINE/PubMed |
spelling | pubmed-49831322016-08-17 Effect of endosulfan on immunological competence of layer birds Singh, P. P. Kumar, Ashok Chauhan, R. S. Pankaj, P. K. Vet World Research Article AIM: The present study was aimed to investigate the immunological competence of endosulfan insecticide after limited oral administration in White Leghorn layer chickens. MATERIALS AND METHODS: A total of 20 White Leghorn birds were given endosulfan in drinking water at 30 ppm/bird/day (no observable effect level dose) for a period of 3-months. Immune competence status of layer birds and chicks hatched from endosulfan offered birds were estimated at 15-day interval in layer birds and at monthly interval in chicks using immunological, biochemical parameters, and teratological estimates. RESULTS: There was a significant decrease in levels of total leukocytes count, absolute lymphocyte count, absolute heterophil count, total serum protein, serum albumin, serum globulin, and serum gamma globulin in the birds fed with endosulfan as compared to control. Similarly, immune competence tests such as lymphocyte stimulation test, oxidative burst assay, and enzyme-linked immunosorbent assay tests indicated lower immunity in birds treated with endosulfan as compared to control. Subsequently, chicks produced from endosulfan-treated birds were also examined for immune competence, but no significant difference was observed between chicks of both the groups. CONCLUSION: The exposure to endosulfan in limited oral dosage was able to exhibit hemo-biochemical and other changes that could be correlated with changes in the immunological profile of layer chickens suggesting cautious usage of endosulfan insecticide in poultry sheds. Veterinary World 2016-07 2016-07-28 /pmc/articles/PMC4983132/ /pubmed/27536042 http://dx.doi.org/10.14202/vetworld.2016.777-782 Text en Copyright: © Singh, et al. http://creativecommons.org/licenses/by/4.0 Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Singh, P. P. Kumar, Ashok Chauhan, R. S. Pankaj, P. K. Effect of endosulfan on immunological competence of layer birds |
title | Effect of endosulfan on immunological competence of layer birds |
title_full | Effect of endosulfan on immunological competence of layer birds |
title_fullStr | Effect of endosulfan on immunological competence of layer birds |
title_full_unstemmed | Effect of endosulfan on immunological competence of layer birds |
title_short | Effect of endosulfan on immunological competence of layer birds |
title_sort | effect of endosulfan on immunological competence of layer birds |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983132/ https://www.ncbi.nlm.nih.gov/pubmed/27536042 http://dx.doi.org/10.14202/vetworld.2016.777-782 |
work_keys_str_mv | AT singhpp effectofendosulfanonimmunologicalcompetenceoflayerbirds AT kumarashok effectofendosulfanonimmunologicalcompetenceoflayerbirds AT chauhanrs effectofendosulfanonimmunologicalcompetenceoflayerbirds AT pankajpk effectofendosulfanonimmunologicalcompetenceoflayerbirds |