Fluoroquinolone Resistance among Clonal Complex 1 Group B Streptococcus Strains

Fluoroquinolone resistance in group B Streptococcus is increasingly being reported worldwide. Here, we correlated fluoroquinolone resistance with mutations in gyrA, gyrB, parC, and parE genes, identified by mining whole-genome sequencing (WGS) data of 190 clonal complex 1 group B Streptococcus strai...

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Autores principales: Neemuchwala, Alefiya, Teatero, Sarah, Patel, Samir N., Fittipaldi, Nahuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983356/
https://www.ncbi.nlm.nih.gov/pubmed/27559344
http://dx.doi.org/10.1155/2016/6403928
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author Neemuchwala, Alefiya
Teatero, Sarah
Patel, Samir N.
Fittipaldi, Nahuel
author_facet Neemuchwala, Alefiya
Teatero, Sarah
Patel, Samir N.
Fittipaldi, Nahuel
author_sort Neemuchwala, Alefiya
collection PubMed
description Fluoroquinolone resistance in group B Streptococcus is increasingly being reported worldwide. Here, we correlated fluoroquinolone resistance with mutations in gyrA, gyrB, parC, and parE genes, identified by mining whole-genome sequencing (WGS) data of 190 clonal complex 1 group B Streptococcus strains recovered from patients with invasive diseases in North America. We report a high prevalence of fluoroquinolone resistance (12%) among GBS strains in our collection. Our approach is the first step towards accurate prediction of fluoroquinolone resistance from WGS data in this opportunistic pathogen.
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spelling pubmed-49833562016-08-24 Fluoroquinolone Resistance among Clonal Complex 1 Group B Streptococcus Strains Neemuchwala, Alefiya Teatero, Sarah Patel, Samir N. Fittipaldi, Nahuel Can J Infect Dis Med Microbiol Research Article Fluoroquinolone resistance in group B Streptococcus is increasingly being reported worldwide. Here, we correlated fluoroquinolone resistance with mutations in gyrA, gyrB, parC, and parE genes, identified by mining whole-genome sequencing (WGS) data of 190 clonal complex 1 group B Streptococcus strains recovered from patients with invasive diseases in North America. We report a high prevalence of fluoroquinolone resistance (12%) among GBS strains in our collection. Our approach is the first step towards accurate prediction of fluoroquinolone resistance from WGS data in this opportunistic pathogen. Hindawi Publishing Corporation 2016 2016-07-31 /pmc/articles/PMC4983356/ /pubmed/27559344 http://dx.doi.org/10.1155/2016/6403928 Text en Copyright © 2016 Alefiya Neemuchwala et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Neemuchwala, Alefiya
Teatero, Sarah
Patel, Samir N.
Fittipaldi, Nahuel
Fluoroquinolone Resistance among Clonal Complex 1 Group B Streptococcus Strains
title Fluoroquinolone Resistance among Clonal Complex 1 Group B Streptococcus Strains
title_full Fluoroquinolone Resistance among Clonal Complex 1 Group B Streptococcus Strains
title_fullStr Fluoroquinolone Resistance among Clonal Complex 1 Group B Streptococcus Strains
title_full_unstemmed Fluoroquinolone Resistance among Clonal Complex 1 Group B Streptococcus Strains
title_short Fluoroquinolone Resistance among Clonal Complex 1 Group B Streptococcus Strains
title_sort fluoroquinolone resistance among clonal complex 1 group b streptococcus strains
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983356/
https://www.ncbi.nlm.nih.gov/pubmed/27559344
http://dx.doi.org/10.1155/2016/6403928
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