Cargando…

The Protective Effect of Low-Dose Ethanol on Myocardial Fibrosis through Downregulating the JNK Signaling Pathway in Diabetic Rats

Objective. To investigate the effects of low dose ethanol feeding in diabetic rats and analyze its underlying mechanisms. Methods. Male Sprague-Dawley rats were divided into 4 groups: control (Con), diabetes at 4 weeks (DM4W), diabetes at 8 weeks (DM8W), and EtOH + DM8W. After 8 weeks, hemodynamic p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Ying, Jia, Xian-Jie, Zhang, Wei-ping, Fang, Ting-ting, Hu, Jie, Ma, Shan-Feng, Gao, Qin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983369/ https://www.ncbi.nlm.nih.gov/pubmed/27547765 http://dx.doi.org/10.1155/2016/3834283

Ejemplares similares

Diabetes Upregulates Oxidative Stress and Downregulates Cardiac Protection to Exacerbate Myocardial Ischemia/Reperfusion Injury in Rats
por: Chien, Chen-Yen, et al.
Publicado: (2020)

Hydrogen sulfide alleviates myocardial fibrosis in mice with alcoholic cardiomyopathy by downregulating autophagy
por: Liang, Biao, et al.
Publicado: (2017)

Atorvastatin Inhibits Myocardial Cell Apoptosis in a Rat Model with Post-myocardial Infarction Heart Failure by Downregulating ER Stress Response
por: Song, Xian Jing, et al.
Publicado: (2011)

Downregulation of lncRNA Miat contributes to the protective effect of electroacupuncture against myocardial fibrosis
por: Qi, Wenchuan, et al.
Publicado: (2022)

Protective Effect of Fustin Against Ethanol-Activated Gastric Ulcer via Downregulation of Biochemical Parameters in Rats
por: Gilani, Sadaf Jamal, et al.
Publicado: (2022)

Effect of genistein on myocardial fibrosis in diabetic rats and its mechanism
por: Yang, Rui, et al.
Publicado: (2018)

The JNK Signaling Pathway in Renal Fibrosis
por: Grynberg, Keren, et al.
Publicado: (2017)

Activation of ALDH2 with Low Concentration of Ethanol Attenuates Myocardial Ischemia/Reperfusion Injury in Diabetes Rat Model
por: Kang, Pin-Fang, et al.
Publicado: (2016)

Rhizoma Paridis saponins ameliorates hepatic fibrosis in rats by downregulating expression of angiogenesis-associated growth factors
por: Han, Yanquan, et al.
Publicado: (2019)

Protective Effects of Sacubitril/Valsartan on Cardiac Fibrosis and Function in Rats With Experimental Myocardial Infarction Involves Inhibition of Collagen Synthesis by Myocardial Fibroblasts Through Downregulating TGF-β1/Smads Pathway
por: Wu, Meifang, et al.
Publicado: (2021)

Remote ischemic post-conditioning protects against myocardial ischemia/reperfusion injury by inhibiting the Rho-kinase signaling pathway
por: Min, Feng, et al.
Publicado: (2020)

Naloxone Postconditioning Alleviates Rat Myocardial Ischemia Reperfusion Injury by Inhibiting JNK Activity
por: Xia, Anzhou, et al.
Publicado: (2014)

miR-382 Contributes to Renal Tubulointerstitial Fibrosis by Downregulating HSPD1
por: Fang, Yi, et al.
Publicado: (2017)

Protective Effects of Astaxanthin on ConA-Induced Autoimmune Hepatitis by the JNK/p-JNK Pathway-Mediated Inhibition of Autophagy and Apoptosis
por: Li, Jingjing, et al.
Publicado: (2015)

JNK Pathway Activation Is Controlled by Tao/TAOK3 to Modulate Ethanol Sensitivity
por: Kapfhamer, David, et al.
Publicado: (2012)

Yes-Associated Protein is Involved in Myocardial Fibrosis in Rats with Diabetic Cardiomyopathy
por: Hu, Maomao, et al.
Publicado: (2021)

Solanum nigrum Protects against Hepatic Fibrosis via Suppression of Hyperglycemia in High-Fat/Ethanol Diet-Induced Rats
por: Tai, Cheng-Jeng, et al.
Publicado: (2016)

Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain in Rats
por: Yi, Zhang, et al.
Publicado: (2015)

Secukinumab and Black Garlic Downregulate OPG/RANK/RANKL Axis and Devitalize Myocardial Interstitial Fibrosis Induced by Sunitinib in Experimental Rats
por: Mohamad, Hoda E., et al.
Publicado: (2023)

Low dose IL‐2 suppress osteoclastogenesis in collagen‐induced arthritis via JNK dependent pathway
por: Sun, Han, et al.
Publicado: (2020)

Prenatal Exposure to Lipopolysaccharide Results in Myocardial Fibrosis in Rat Offspring
por: Chen, Xin, et al.
Publicado: (2015)

RIP3 deficiency attenuated hepatic stellate cell activation and liver fibrosis in schistosomiasis through JNK-cJUN/Egr1 downregulation
por: Song, Li-Jun, et al.
Publicado: (2022)

Dihydrolycorine Attenuates Cardiac Fibrosis and Dysfunction by Downregulating Runx1 following Myocardial Infarction
por: Ni, Tingjuan, et al.
Publicado: (2021)

Biliverdin administration ameliorates cerebral ischemia reperfusion injury in rats and is associated with proinflammatory factor downregulation
por: Li, Jun-Jie, et al.
Publicado: (2017)

Inhibition of Rat Muscle and Liver Phosphofructokinases by High Doses of Ethanol
por: Lelevich, Sergey Vladimirovich, et al.
Publicado: (2013)

Protective and therapeutic effects of ethanolic extract of Nasturtium officinale (watercress) and vitamin E against bleomycin-induced pulmonary fibrosis in rats
por: Ramezani, Sanaz, et al.
Publicado: (2020)

The Protective Effect of Low Dose of Lipopolysaccharide Pretreatment on Endotoxin-Induced Uveitis in Rats Is Associated with Downregulation of CSF-1 and Upregulation of LRR-1
por: Ling, Yunli, et al.
Publicado: (2020)

Regulatory role of the TLR4/JNK signaling pathway in sepsis-induced myocardial dysfunction
por: Chang, Chao, et al.
Publicado: (2021)

The protective effect of polyphyllin I on myocardial ischemia/reperfusion injury in rats
por: Huang, Ruizhen, et al.
Publicado: (2020)

Low-dose aspirin protects unexplained recurrent spontaneous abortion via downregulation of HMGB1 inflammation activation
por: Xu, Xiaofeng, et al.
Publicado: (2022)

Effects of imipenem combined with low-dose cyclophosphamide on the intestinal barrier in septic rats
por: Guo, Peng, et al.
Publicado: (2018)

Protective Effect of Electroacupuncture at Zusanli on Myocardial Injury in Septic Rats
por: Zhang, Lijian, et al.
Publicado: (2018)

High-Dose Fluoride Impairs the Properties of Human Embryonic Stem Cells via JNK Signaling
por: Fu, Xin, et al.
Publicado: (2016)

Exogenous H(2)S mitigates myocardial fibrosis in diabetic rats through suppression of the canonical Wnt pathway
por: Yang, Rui, et al.
Publicado: (2019)

Mitochondrial Aldehyde Dehydrogenase 2 Plays Protective Roles in Heart Failure After Myocardial Infarction via Suppression of the Cytosolic JNK/p53 Pathway in Mice
por: Sun, Aijun, et al.
Publicado: (2014)

Downregulation of microRNA-218 is cardioprotective against cardiac fibrosis and cardiac function impairment in myocardial infarction by binding to MITF
por: Qian, Linfeng, et al.
Publicado: (2019)

Inhibition of P38 MAPK Downregulates the Expression of IL-1β to Protect Lung from Acute Injury in Intestinal Ischemia Reperfusion Rats
por: Zheng, De-Yi, et al.
Publicado: (2016)

Lipoxin A(4) Preconditioning and Postconditioning Protect Myocardial Ischemia/Reperfusion Injury in Rats
por: Zhao, Qifeng, et al.
Publicado: (2013)

Downregulation of alpha7 nicotinic acetylcholine receptor in two-kidney one-clip hypertensive rats
por: Chen, Ji-Kuai, et al.
Publicado: (2012)

Salvianolic Acid B Attenuates Rat Hepatic Fibrosis via Downregulating Angiotensin II Signaling
por: Li, Shu, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_usmubkdbrh10hc5dcget51df8h