Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer

[Image: see text] After a high-throughput screening campaign identified thioether 1 as an antagonist of the nuclear androgen receptor, a zone model was developed for structure–activity relationship (SAR) purposes and analogues were synthesized and evaluated in a cell-based luciferase assay. A novel...

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Detalles Bibliográficos
Autores principales: Johnson, James K., Skoda, Erin M., Zhou, Jianhua, Parrinello, Erica, Wang, Dan, O’Malley, Katherine, Eyer, Benjamin R., Kazancioglu, Mustafa, Eisermann, Kurtis, Johnston, Paul A., Nelson, Joel B., Wang, Zhou, Wipf, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983742/
https://www.ncbi.nlm.nih.gov/pubmed/27563404
http://dx.doi.org/10.1021/acsmedchemlett.6b00186

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