Cargando…
The importance of ribosome production, and the 5S RNP–MDM2 pathway, in health and disease
Ribosomes are abundant, large RNA–protein complexes that are the source of all protein synthesis in the cell. The production of ribosomes is an extremely energetically expensive cellular process that has long been linked to human health and disease. More recently, it has been shown that ribosome bio...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984446/ https://www.ncbi.nlm.nih.gov/pubmed/27528756 http://dx.doi.org/10.1042/BST20160106 |
_version_ | 1782447963402928128 |
---|---|
author | Pelava, Andria Schneider, Claudia Watkins, Nicholas J. |
author_facet | Pelava, Andria Schneider, Claudia Watkins, Nicholas J. |
author_sort | Pelava, Andria |
collection | PubMed |
description | Ribosomes are abundant, large RNA–protein complexes that are the source of all protein synthesis in the cell. The production of ribosomes is an extremely energetically expensive cellular process that has long been linked to human health and disease. More recently, it has been shown that ribosome biogenesis is intimately linked to multiple cellular signalling pathways and that defects in ribosome production can lead to a wide variety of human diseases. Furthermore, changes in ribosome production in response to nutrient levels in the diet lead to metabolic re-programming of the liver. Reduced or abnormal ribosome production in response to cellular stress or mutations in genes encoding factors critical for ribosome biogenesis causes the activation of the tumour suppressor p53, which leads to re-programming of cellular transcription. The ribosomal assembly intermediate 5S RNP (ribonucleoprotein particle), containing RPL5, RPL11 and the 5S rRNA, accumulates when ribosome biogenesis is blocked. The excess 5S RNP binds to murine double minute 2 (MDM2), the main p53-suppressor in the cell, inhibiting its function and leading to p53 activation. Here, we discuss the involvement of ribosome biogenesis in the homoeostasis of p53 in the cell and in human health and disease. |
format | Online Article Text |
id | pubmed-4984446 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-49844462016-08-25 The importance of ribosome production, and the 5S RNP–MDM2 pathway, in health and disease Pelava, Andria Schneider, Claudia Watkins, Nicholas J. Biochem Soc Trans Biochemical Society Focused Meetings Ribosomes are abundant, large RNA–protein complexes that are the source of all protein synthesis in the cell. The production of ribosomes is an extremely energetically expensive cellular process that has long been linked to human health and disease. More recently, it has been shown that ribosome biogenesis is intimately linked to multiple cellular signalling pathways and that defects in ribosome production can lead to a wide variety of human diseases. Furthermore, changes in ribosome production in response to nutrient levels in the diet lead to metabolic re-programming of the liver. Reduced or abnormal ribosome production in response to cellular stress or mutations in genes encoding factors critical for ribosome biogenesis causes the activation of the tumour suppressor p53, which leads to re-programming of cellular transcription. The ribosomal assembly intermediate 5S RNP (ribonucleoprotein particle), containing RPL5, RPL11 and the 5S rRNA, accumulates when ribosome biogenesis is blocked. The excess 5S RNP binds to murine double minute 2 (MDM2), the main p53-suppressor in the cell, inhibiting its function and leading to p53 activation. Here, we discuss the involvement of ribosome biogenesis in the homoeostasis of p53 in the cell and in human health and disease. Portland Press Ltd. 2016-08-15 2016-08-15 /pmc/articles/PMC4984446/ /pubmed/27528756 http://dx.doi.org/10.1042/BST20160106 Text en © 2016 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Biochemical Society Focused Meetings Pelava, Andria Schneider, Claudia Watkins, Nicholas J. The importance of ribosome production, and the 5S RNP–MDM2 pathway, in health and disease |
title | The importance of ribosome production, and the 5S RNP–MDM2 pathway, in health and disease |
title_full | The importance of ribosome production, and the 5S RNP–MDM2 pathway, in health and disease |
title_fullStr | The importance of ribosome production, and the 5S RNP–MDM2 pathway, in health and disease |
title_full_unstemmed | The importance of ribosome production, and the 5S RNP–MDM2 pathway, in health and disease |
title_short | The importance of ribosome production, and the 5S RNP–MDM2 pathway, in health and disease |
title_sort | importance of ribosome production, and the 5s rnp–mdm2 pathway, in health and disease |
topic | Biochemical Society Focused Meetings |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984446/ https://www.ncbi.nlm.nih.gov/pubmed/27528756 http://dx.doi.org/10.1042/BST20160106 |
work_keys_str_mv | AT pelavaandria theimportanceofribosomeproductionandthe5srnpmdm2pathwayinhealthanddisease AT schneiderclaudia theimportanceofribosomeproductionandthe5srnpmdm2pathwayinhealthanddisease AT watkinsnicholasj theimportanceofribosomeproductionandthe5srnpmdm2pathwayinhealthanddisease AT pelavaandria importanceofribosomeproductionandthe5srnpmdm2pathwayinhealthanddisease AT schneiderclaudia importanceofribosomeproductionandthe5srnpmdm2pathwayinhealthanddisease AT watkinsnicholasj importanceofribosomeproductionandthe5srnpmdm2pathwayinhealthanddisease |