Mutational analysis of anal cancers demonstrates frequent PIK3CA mutations associated with poor outcome after salvage abdominoperineal resection

BACKGROUND: A better understanding of the molecular profile of anal squamous cell carcinomas (ASCCs) is necessary to consider new therapeutic approaches, and the identification of prognostic and predictive factors for response to treatment. METHODS: We retrospectively analysed tumours from ASCC pati...

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Detalles Bibliográficos
Autores principales: Cacheux, Wulfran, Rouleau, Etienne, Briaux, Adrien, Tsantoulis, Petros, Mariani, Pascale, Richard-Molard, Marion, Buecher, Bruno, Dangles-Marie, Virginie, Richon, Sophie, Lazartigues, Julien, Jeannot, Emmanuelle, Farkhondeh, Fereshteh, Sastre-Garau, Xavier, de La Rochefordière, Anne, Labib, Alain, Falcou, Marie-Christine, Stevens, Denise, Roth, Arnaud, Roman-Roman, Sergio, Mitry, Emmanuel, Bièche, Ivan, Lièvre, Astrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984471/
https://www.ncbi.nlm.nih.gov/pubmed/27219019
http://dx.doi.org/10.1038/bjc.2016.144

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