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A circulating miRNA assay as a first-line test for prostate cancer screening
BACKGROUND: Prostate cancer (PCa) screening currently relies on prostate-specific antigen (PSA) testing and digital rectal examination. However, recent large-scale studies have questioned the long-term efficacy of these tests, and biomarkers that accurately identify PCa are needed. METHODS: We analy...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984473/ https://www.ncbi.nlm.nih.gov/pubmed/27228285 http://dx.doi.org/10.1038/bjc.2016.151 |
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author | Sharova, Evgeniya Grassi, Angela Marcer, Anna Ruggero, Katia Pinto, Francesco Bassi, Pierfrancesco Zanovello, Paola Zattoni, Filiberto D'Agostino, Donna M Iafrate, Massimo Ciminale, Vincenzo |
author_facet | Sharova, Evgeniya Grassi, Angela Marcer, Anna Ruggero, Katia Pinto, Francesco Bassi, Pierfrancesco Zanovello, Paola Zattoni, Filiberto D'Agostino, Donna M Iafrate, Massimo Ciminale, Vincenzo |
author_sort | Sharova, Evgeniya |
collection | PubMed |
description | BACKGROUND: Prostate cancer (PCa) screening currently relies on prostate-specific antigen (PSA) testing and digital rectal examination. However, recent large-scale studies have questioned the long-term efficacy of these tests, and biomarkers that accurately identify PCa are needed. METHODS: We analysed the levels of circulating microRNAs (miRNAs) in patients with elevated PSA who were diagnosed with either localised PCa (n=36) or benign prostatic hyperplasia (BPH, n=31) upon biopsy. Real-time RT–PCR with Taqman probes was used to measure plasma levels of miRNAs. To circumvent problems associated with circulating miRNA quantitation, we computed the expression ratios of upregulated and downregulated miRNAs. RESULTS: The miR-106a/miR-130b and miR-106a/miR-223 ratios were significantly different between the biopsy-positive and BPH groups (P<0.0001), and yielded statistical power values that were >0.99. Both miRNA ratios were highly sensitive and more specific than PSA in discriminating localised PCa from BPH. Receiver operating characteristic curve analysis revealed area under curve values of 0.81 (miR-106a/miR-130b) and 0.77 (miR-106a/miR-223). CONCLUSIONS: Testing for circulating miR-106a/miR-130b and miR-106a/miR-223 ratios may reduce the costs and morbidity of unnecessary biopsies and is feasible for large-scale screening, as it requires measuring only three miRNAs. |
format | Online Article Text |
id | pubmed-4984473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49844732017-06-14 A circulating miRNA assay as a first-line test for prostate cancer screening Sharova, Evgeniya Grassi, Angela Marcer, Anna Ruggero, Katia Pinto, Francesco Bassi, Pierfrancesco Zanovello, Paola Zattoni, Filiberto D'Agostino, Donna M Iafrate, Massimo Ciminale, Vincenzo Br J Cancer Molecular Diagnostics BACKGROUND: Prostate cancer (PCa) screening currently relies on prostate-specific antigen (PSA) testing and digital rectal examination. However, recent large-scale studies have questioned the long-term efficacy of these tests, and biomarkers that accurately identify PCa are needed. METHODS: We analysed the levels of circulating microRNAs (miRNAs) in patients with elevated PSA who were diagnosed with either localised PCa (n=36) or benign prostatic hyperplasia (BPH, n=31) upon biopsy. Real-time RT–PCR with Taqman probes was used to measure plasma levels of miRNAs. To circumvent problems associated with circulating miRNA quantitation, we computed the expression ratios of upregulated and downregulated miRNAs. RESULTS: The miR-106a/miR-130b and miR-106a/miR-223 ratios were significantly different between the biopsy-positive and BPH groups (P<0.0001), and yielded statistical power values that were >0.99. Both miRNA ratios were highly sensitive and more specific than PSA in discriminating localised PCa from BPH. Receiver operating characteristic curve analysis revealed area under curve values of 0.81 (miR-106a/miR-130b) and 0.77 (miR-106a/miR-223). CONCLUSIONS: Testing for circulating miR-106a/miR-130b and miR-106a/miR-223 ratios may reduce the costs and morbidity of unnecessary biopsies and is feasible for large-scale screening, as it requires measuring only three miRNAs. Nature Publishing Group 2016-06-14 2016-05-26 /pmc/articles/PMC4984473/ /pubmed/27228285 http://dx.doi.org/10.1038/bjc.2016.151 Text en Copyright © 2016 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Molecular Diagnostics Sharova, Evgeniya Grassi, Angela Marcer, Anna Ruggero, Katia Pinto, Francesco Bassi, Pierfrancesco Zanovello, Paola Zattoni, Filiberto D'Agostino, Donna M Iafrate, Massimo Ciminale, Vincenzo A circulating miRNA assay as a first-line test for prostate cancer screening |
title | A circulating miRNA assay as a first-line test for prostate cancer screening |
title_full | A circulating miRNA assay as a first-line test for prostate cancer screening |
title_fullStr | A circulating miRNA assay as a first-line test for prostate cancer screening |
title_full_unstemmed | A circulating miRNA assay as a first-line test for prostate cancer screening |
title_short | A circulating miRNA assay as a first-line test for prostate cancer screening |
title_sort | circulating mirna assay as a first-line test for prostate cancer screening |
topic | Molecular Diagnostics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984473/ https://www.ncbi.nlm.nih.gov/pubmed/27228285 http://dx.doi.org/10.1038/bjc.2016.151 |
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