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Hallmarks of cancer stem cell metabolism
Cancer cells adapt cellular metabolism to cope with their high proliferation rate. Instead of primarily using oxidative phosphorylation (OXPHOS), cancer cells use less efficient glycolysis for the production of ATP and building blocks (Warburg effect). However, tumours are not uniform, but rather fu...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984474/ https://www.ncbi.nlm.nih.gov/pubmed/27219018 http://dx.doi.org/10.1038/bjc.2016.152 |
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author | Sancho, Patricia Barneda, David Heeschen, Christopher |
author_facet | Sancho, Patricia Barneda, David Heeschen, Christopher |
author_sort | Sancho, Patricia |
collection | PubMed |
description | Cancer cells adapt cellular metabolism to cope with their high proliferation rate. Instead of primarily using oxidative phosphorylation (OXPHOS), cancer cells use less efficient glycolysis for the production of ATP and building blocks (Warburg effect). However, tumours are not uniform, but rather functionally heterogeneous and harbour a subset of cancer cells with stemness features. Such cancer cells have the ability to repopulate the entire tumour and thus have been termed cancer stem cells (CSCs) or tumour-initiating cells (TICs). As opposed to differentiated bulk tumour cells relying on glycolysis, CSCs show a distinct metabolic phenotype that, depending on the cancer type, can be highly glycolytic or OXPHOS dependent. In either case, mitochondrial function is critical and takes centre stage in CSC functionality. Remaining controversies in this young and emerging research field may be related to CSC isolation techniques and/or the use of less suitable model systems. Still, the apparent dependence of CSCs on mitochondrial function, regardless of their primary metabolic phenotype, represents a previously unrecognised Achilles heel amendable for therapeutic intervention. Elimination of highly chemoresistant CSCs as the root of many cancers via inhibition of mitochondrial function bears the potential to prevent relapse from disease and thus improve patients' long-term outcome. |
format | Online Article Text |
id | pubmed-4984474 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49844742016-08-25 Hallmarks of cancer stem cell metabolism Sancho, Patricia Barneda, David Heeschen, Christopher Br J Cancer Minireview Cancer cells adapt cellular metabolism to cope with their high proliferation rate. Instead of primarily using oxidative phosphorylation (OXPHOS), cancer cells use less efficient glycolysis for the production of ATP and building blocks (Warburg effect). However, tumours are not uniform, but rather functionally heterogeneous and harbour a subset of cancer cells with stemness features. Such cancer cells have the ability to repopulate the entire tumour and thus have been termed cancer stem cells (CSCs) or tumour-initiating cells (TICs). As opposed to differentiated bulk tumour cells relying on glycolysis, CSCs show a distinct metabolic phenotype that, depending on the cancer type, can be highly glycolytic or OXPHOS dependent. In either case, mitochondrial function is critical and takes centre stage in CSC functionality. Remaining controversies in this young and emerging research field may be related to CSC isolation techniques and/or the use of less suitable model systems. Still, the apparent dependence of CSCs on mitochondrial function, regardless of their primary metabolic phenotype, represents a previously unrecognised Achilles heel amendable for therapeutic intervention. Elimination of highly chemoresistant CSCs as the root of many cancers via inhibition of mitochondrial function bears the potential to prevent relapse from disease and thus improve patients' long-term outcome. Nature Publishing Group 2016-06-14 2016-05-24 /pmc/articles/PMC4984474/ /pubmed/27219018 http://dx.doi.org/10.1038/bjc.2016.152 Text en Copyright © 2016 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under the Creative Commons Attribution-Non-Commercial-Share Alike 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Minireview Sancho, Patricia Barneda, David Heeschen, Christopher Hallmarks of cancer stem cell metabolism |
title | Hallmarks of cancer stem cell metabolism |
title_full | Hallmarks of cancer stem cell metabolism |
title_fullStr | Hallmarks of cancer stem cell metabolism |
title_full_unstemmed | Hallmarks of cancer stem cell metabolism |
title_short | Hallmarks of cancer stem cell metabolism |
title_sort | hallmarks of cancer stem cell metabolism |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984474/ https://www.ncbi.nlm.nih.gov/pubmed/27219018 http://dx.doi.org/10.1038/bjc.2016.152 |
work_keys_str_mv | AT sanchopatricia hallmarksofcancerstemcellmetabolism AT barnedadavid hallmarksofcancerstemcellmetabolism AT heeschenchristopher hallmarksofcancerstemcellmetabolism |