Association of CpG island methylator phenotype and EREG/AREG methylation and expression in colorectal cancer

BACKGROUND: High EREG and AREG expression, and left-sided primary tumours are associated with superior efficacy of anti-epidermal growth factor receptor (EGFR) therapy in metastatic colorectal cancer (CRC), but a unifying explanation of these findings is lacking. METHODS: RNA-seq, gene expression ar...

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Detalles Bibliográficos
Autores principales: Lee, Michael S, McGuffey, Elizabeth J, Morris, Jeffrey S, Manyam, Ganiraju, Baladandayuthapani, Veerabahdran, Wei, Wei, Morris, Van K, Overman, Michael J, Maru, Dipen M, Jiang, Zhi-Qin, Hamilton, Stanley R, Kopetz, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984478/
https://www.ncbi.nlm.nih.gov/pubmed/27272216
http://dx.doi.org/10.1038/bjc.2016.87

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984478/
https://www.ncbi.nlm.nih.gov/pubmed/27272216
http://dx.doi.org/10.1038/bjc.2016.87

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